Oxygen-deficient titanium dioxide-loaded black phosphorus nanosheets for synergistic photothermal and sonodynamic
Wenxiang Du1, Weijian Chen1, Jing Wang2
1State Key Laboratory of Fire Science, University of Science and Technology of China, Huangshan Road 443, Hefei, Anhui, PR China; CAS Key Lab of Soft Matter Chemistry, School of Chemistry and Materials Science, University of Science and Technology of China, Jinzhai Road 96, Hefei, Anhui, PR China.
Abstract:
Malignant tumors, particularly those located in deep tissues, have always been a grievous threat to human health. Sonodynamic therapy (SDT) has recently attracted great attention due to deep tissue penetration. However, the lack of effective sonosensitizers and the poor therapeutic efficacy severely limit their wider use. Herein, dual-functionalized black phosphorus nanosheets (BP@PEI-PEG, i.e., PPBP) integrating black oxygen-deficient titanium dioxide particles (B-TiO2) were successfully constructed (PPBP-B-TiO2) for synergistic photothermal (PTT)/sonodynamic therapy. In these nanocomposites, black titanium dioxide can enhance the separation of electrons (e-) and holes (h+) due to the oxygen-deficient structure and significantly improves the production of reactive oxygen species (ROS) for SDT, while the BP nanosheets endow the nanocomposites with a higher photothermal conversion capability for photothermal therapy (η = 44.1%) which can prolong the blood circulation and improve the O2 supply. In vivo experiments prove that PPBP-B-TiO2 nanocomposites exhibited outstanding tumor inhibition efficacy and excellent biocompatibility. This work provides a prospective platform for combined photothermal/sonodynamic cancer therapy.
Insights
This study introduces novel nanocomposites for combined photothermal and sonodynamic cancer therapy. These materials show significant tumor inhibition and excellent biocompatibility, offering a promising new approach for treating deep-seated malignant tumors.
Area of Science:
- Biomedical Engineering
- Materials Science
- Oncology
Background:
- Malignant tumors in deep tissues pose significant health challenges.
- Sonodynamic therapy (SDT) offers deep tissue penetration but suffers from limited sensitizers and efficacy.
- Photothermal therapy (PTT) is another promising cancer treatment modality.
Purpose of the Study:
- To develop dual-functionalized black phosphorus nanosheets integrated with black oxygen-deficient titanium dioxide particles (PPBP-B-TiO2) for synergistic PTT/SDT.
- To evaluate the efficacy and biocompatibility of the developed nanocomposites for cancer therapy.
Main Methods:
- Construction of PPBP-B-TiO2 nanocomposites.
- Characterization of electron-hole separation and reactive oxygen species (ROS) generation.
- Assessment of photothermal conversion efficiency (η = 44.1%).
- In vivo evaluation of tumor inhibition and biocompatibility.
Main Results:
- The oxygen-deficient structure of B-TiO2 enhances ROS production for SDT.
- BP nanosheets provide high photothermal conversion efficiency for PTT.
- PPBP-B-TiO2 nanocomposites demonstrated significant tumor inhibition in vivo.
- The developed materials exhibited excellent biocompatibility.
Conclusions:
- PPBP-B-TiO2 nanocomposites are effective for synergistic photothermal and sonodynamic cancer therapy.
- This platform shows potential for treating deep-seated malignant tumors.
- The study highlights a promising strategy for advanced cancer treatment.
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