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Dextrose administration exacerbates acute renal ischemic damage in anesthetized dogs
Archives of Surgery (Chicago, Ill. : 1960)
|July 1, 1987
Summary
Dextrose administration during normothermic renal ischemia significantly worsened kidney function. This study in dogs shows higher plasma creatinine levels when dextrose was given, indicating detrimental effects on renal function.
Area of Science:
- Nephrology
- Physiology
- Surgical Research
Background:
- Normothermic renal ischemia can lead to kidney injury.
- The impact of hyperglycemia on renal outcomes during ischemia is not fully understood.
Purpose of the Study:
- To investigate the detrimental effects of moderate hyperglycemia induced by dextrose administration on renal function during normothermic ischemia.
Main Methods:
- Mongrel dogs underwent unilateral nephrectomy and 60 minutes of renal artery and vein occlusion.
- Groups received either lactated Ringer's solution (LR) or 5% dextrose in lactated Ringer's solution (D5LR).
- Plasma creatinine levels were monitored for 30 hours post-ischemia.
Main Results:
- Dogs receiving D5LR exhibited a significantly greater increase in plasma creatinine compared to the LR group.
- Hyperglycemia was confirmed by elevated blood glucose levels in the D5LR group.
- Sham-operated dogs showed stable plasma creatinine levels.
Conclusions:
- Dextrose administration exacerbates renal dysfunction following normothermic ischemia.
- Maintaining normoglycemia may be crucial for preserving renal function during ischemic events.