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Iron oxide nanoparticles for biomedical applications: an updated patent review (2015-2021)
Zeyuan Mao1, Xin Li1, Pengfei Wang1
1Chongqing Key Laboratory of Natural Product Synthesis and Drug Research, School of Pharmaceutical Sciences, Chongqing University, Chongqing, People's Republic of China.
Introduction:
Iron oxide nanoparticles (IONPs) hold the edges of great magnetic properties and fine nanoparticle characteristics, making them an attractive therapeutic agent. In the past seven years, more in-depth investigations were devoted to the intrinsic structure, magnetic properties, and biological effects of IONPs, expanding the range of their therapeutic application scenes.
Areas Covered:
This review focuses on the development of IONPs for biomedical applications from the angle of the patent literature reported during the period 2015-2021.
Expert Opinion:
While the magnetic properties of IONPs have been extensively explored, the precise control of IONP behavior through external magnetic fields remains a challenge. Further digging into the biological effects of IONPs will facilitate the development of IONP-based immune therapies. Long-term reliable safety evaluations are of necessity and significance to promote the process of clinical translation.
