Related Experiment Video

Updated: Sep 2, 2025

5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats
05:34

5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats

Published on: April 4, 2025

803

COVID-19 outbreak and the impact on renal disorders: A rapid review

Behzad Lotfi1, Mohsen Mohammadrahimi2, Sakineh Hajebrahimi1

  • 1Research Center for Evidence-Based Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.

Turkish Journal of Urology
|August 5, 2022
PubMed

Insights

Coronavirus disease 2019 (COVID-19) significantly impacts kidney function and increases mortality risk in patients with kidney diseases. Acute kidney injury (AKI) in COVID-19 patients is associated with very high mortality rates, necessitating further research.

Area of Science:

  • Nephrology
  • Infectious Diseases
  • Critical Care Medicine

Background:

  • The coronavirus disease 2019 (COVID-19) pandemic has raised concerns about its impact on various organ systems.
  • Patients with pre-existing kidney diseases may be particularly vulnerable to severe outcomes from COVID-19.

Purpose of the Study:

  • To evaluate the effects of COVID-19 on renal function and mortality in patients with kidney diseases.
  • To synthesize current evidence on the association between COVID-19 and kidney complications.

Main Methods:

  • A rapid review methodology was employed, searching multiple databases including MEDLINE, Scopus, and Web of Science.
  • Included studies underwent screening of titles, abstracts, and full texts, with 10 articles selected for qualitative synthesis.
  • A meta-analysis was performed on binary data from 5 eligible studies comprising 964 COVID-19 positive patients.

Main Results:

  • The cumulative incidence of acute kidney injury (AKI) among COVID-19 patients was 7.1% (95% CI: 1.8%-24.5%).
  • Qualitative synthesis indicated a higher risk of in-hospital mortality for patients with COVID-19 and kidney diseases.
  • The occurrence of AKI in the context of COVID-19 was linked to a very high mortality rate.

Conclusions:

  • COVID-19 poses a significant threat to patients with kidney diseases, increasing their risk of AKI and in-hospital mortality.
  • Further extensive research is crucial to fully understand the extent and mechanisms of renal involvement in COVID-19.
  • Early recognition and management of kidney complications in COVID-19 patients are critical.

More Related Videos

A Large Animal Model for Acute Kidney Injury by Temporary Bilateral Renal Artery Occlusion09:02

A Large Animal Model for Acute Kidney Injury by Temporary Bilateral Renal Artery Occlusion

Published on: February 2, 2021

4.6K
Isolation, Characterization, And High Throughput Extracellular Flux Analysis of Mouse Primary Renal Tubular Epithelial Cells09:40

Isolation, Characterization, And High Throughput Extracellular Flux Analysis of Mouse Primary Renal Tubular Epithelial Cells

Published on: June 20, 2018

17.8K

Related Concept Videos

Renal Drug Clearance: Overview01:06

Renal Drug Clearance: Overview

Renal clearance is a crucial parameter in pharmacokinetics that quantifies the rate at which the kidneys excrete a drug. It represents a constant fraction of the central volume of distribution containing the drug that the kidney eliminates per unit of time.
Renal clearance can be calculated using different methods. One approach is to divide the urinary drug excretion rate by the plasma drug concentration. This method directly measures renal clearance, indicating the kidneys' efficiency in...
316
Acute Kidney Injury II: Pathophysiology01:29

Acute Kidney Injury II: Pathophysiology

Acute kidney injury (AKI) causes are categorized into three primary categories based on the location of the injury: prerenal, intrarenal (or intrinsic), and postrenal causes. This classification guides clinical management and illustrates how different pathways can impair kidney function.Etiology and Pathophysiology of Acute Kidney Injury1. Prerenal causesEtiology: Prerenal Acute Kidney Injury, the most common type, occurs when reduced blood flow to the kidneys decreases filtration capacity...
64
Acute Kidney Injury III: Clinical Manifestations01:29

Acute Kidney Injury III: Clinical Manifestations

Acute Kidney Injury (AKI) progresses through distinct clinical phases: the oliguric, diuretic, and recovery phases, each marked by unique manifestations and challenges.Oliguric Phase:The oliguric phase is the initial stage of AKI, typically lasting 10 to 14 days. This phase is marked by a significant reduction in urine output, usually less than 400 mL per day, indicating decreased kidney function. Fluid retention is a prominent feature, leading to symptoms such as edema, hypertension, and...
78
Acute Kidney Injury I: Introduction01:22

Acute Kidney Injury I: Introduction

Introduction:Acute Kidney Injury (AKI) describes a swift decrease in kidney function occurring over hours to days, characterized by the kidneys' failure to remove waste products from the bloodstream. This leads to dangerous complications like metabolic acidosis, fluid overload, and electrolyte imbalances, such as hyperkalemia, which can cause life-threatening arrhythmias. AKI is common in both hospital and outpatient settings, often triggered by dehydration, sepsis, or exposure to nephrotoxic...
66
Factors Affecting Renal Clearance: Renal Impairment01:17

Factors Affecting Renal Clearance: Renal Impairment

Renal dysfunction significantly impairs the renal clearance of drugs, leading to potential complications in drug therapy. Renal failure, which can be caused by various factors, poses a significant challenge in the elimination of drugs from the body.
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
153
Acute Kidney Injury IV: Diagnostic Studies and Prevention01:30

Acute Kidney Injury IV: Diagnostic Studies and Prevention

Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
56