Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders01:27

Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders

913
Schizophrenia is a neurodevelopmental disorder whose origins are rooted in complex genetic components. Despite our burgeoning understanding, the pathophysiology of this disorder remains incompletely deciphered.
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within...
913
Biological Causes of Schizophrenia01:29

Biological Causes of Schizophrenia

133
Schizophrenia, a severe psychiatric disorder, arises from a complex interplay of biological factors, including genetic predisposition, structural brain abnormalities, neurotransmitter dysregulation, and developmental irregularities. These factors collectively contribute to the onset and progression of the disorder, which typically manifests in late adolescence or early adulthood.
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin...
133
Covalently Linked Protein Regulators02:04

Covalently Linked Protein Regulators

7.0K
Proteins can undergo many types of post-translational modifications, often in response to changes in their environment. These modifications play an important role in the function and stability of these proteins. Covalently linked molecules include functional groups, such as methyl, acetyl, and phosphate groups, and also small proteins, such as ubiquitin. There are around 200 different types of covalent regulators that have been identified.
These groups modify specific amino acids in a protein....
7.0K
Protein Modifications in the RER01:26

Protein Modifications in the RER

5.5K
Modification of secretory and transmembrane proteins entering the rough ER begins in the ER lumen. These modifications aid in protein folding and stabilize the acquired tertiary structure. Protein modifications in the rough ER co-occur at different stages of protein folding.
Broadly, these modifications can be categorized into four main categories — glycosylation, formation of disulfide bonds, assembly of protein subunits, and specific proteolytic cleavages like removal of signal...
5.5K
Nuclear Export of mRNA02:31

Nuclear Export of mRNA

7.8K
Before mRNAs are exported to the cytoplasm, it is crucial to check each mRNA for structural and functional integrity. Eukaryotic cells use several different mechanisms, collectively known as mRNA surveillance, to look for irregularities in mRNAs. Irregular or aberrant mRNA are rapidly degraded by various enzymes. If a defective mRNA escapes the surveillance, it would be translated into a protein which would either be non-functional or not function properly. One of the primary irregularities in...
7.8K
Psychological and Sociocultural Causes of Schizophrenia01:29

Psychological and Sociocultural Causes of Schizophrenia

179
Schizophrenia, a complex psychiatric disorder, has been historically misunderstood. Early psychological theories attributed its origins to childhood trauma and unresponsive parenting. However, contemporary research largely rejects these notions, favoring the vulnerability-stress hypothesis. This model proposes that individuals with a genetic predisposition to schizophrenia may develop the disorder following exposure to significant environmental stressors. Notably, studies on high-risk...
179

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Engineering glyphosate tolerance in sugarcane through overexpression of a mutated version of its native <i>EPSPS</i> gene.

GM crops & food·2026
Same author

Plasma Proteomic Profile of Chemotherapy-Induced Severe Neutropenia: A Pilot Discovery Phase Study.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology·2026
Same author

HIF-1 attenuates high-fiber diet-mediated proliferation and stemness of colonic epithelium.

Gut microbes·2025
Same author

Impacts of hnRNP A1 Splicing Inhibition on the Brain Remyelination Proteome.

Journal of neurochemistry·2025
Same author

The autophagy proteome in the brain.

Journal of neurochemistry·2024
Same author

Changes in neuroinflammatory biomarkers correlate with disease severity and neuroimaging alterations in patients with COVID-19 neurological complications.

Brain, behavior, & immunity - health·2024

Related Experiment Video

Updated: Sep 2, 2025

Utilizing a Comprehensive Immunoprecipitation Enrichment System to Identify an Endogenous Post-translational Modification Profile for Target Proteins
08:12

Utilizing a Comprehensive Immunoprecipitation Enrichment System to Identify an Endogenous Post-translational Modification Profile for Target Proteins

Published on: January 8, 2018

11.4K

Known and Unexplored Post-Translational Modification Pathways in Schizophrenia.

Bradley J Smith1, Victor C Carregari2

  • 1Laboratory of Neuroproteomics, Department of Cell and Tissue Biology, Institute of Biology, State University of Campinas, Campinas, SP, Brazil. smith.unicamp@gmail.com.

Advances in Experimental Medicine and Biology
|August 5, 2022
PubMed
Summary

Post-translational modifications (PTMs) impact protein function across life. Studying PTMs in schizophrenia reveals disease mechanisms and potential therapeutic targets, though many pathways remain unexplored.

Keywords:
Mass spectrometryPost-translational modificationsProteomicsSchizophrenia

More Related Videos

Characterizing Histone Post-translational Modification Alterations in Yeast Neurodegenerative Proteinopathy Models
08:33

Characterizing Histone Post-translational Modification Alterations in Yeast Neurodegenerative Proteinopathy Models

Published on: March 24, 2019

7.6K
A Strategy to Identify de Novo Mutations in Common Disorders such as Autism and Schizophrenia
05:51

A Strategy to Identify de Novo Mutations in Common Disorders such as Autism and Schizophrenia

Published on: June 15, 2011

26.0K

Related Experiment Videos

Last Updated: Sep 2, 2025

Utilizing a Comprehensive Immunoprecipitation Enrichment System to Identify an Endogenous Post-translational Modification Profile for Target Proteins
08:12

Utilizing a Comprehensive Immunoprecipitation Enrichment System to Identify an Endogenous Post-translational Modification Profile for Target Proteins

Published on: January 8, 2018

11.4K
Characterizing Histone Post-translational Modification Alterations in Yeast Neurodegenerative Proteinopathy Models
08:33

Characterizing Histone Post-translational Modification Alterations in Yeast Neurodegenerative Proteinopathy Models

Published on: March 24, 2019

7.6K
A Strategy to Identify de Novo Mutations in Common Disorders such as Autism and Schizophrenia
05:51

A Strategy to Identify de Novo Mutations in Common Disorders such as Autism and Schizophrenia

Published on: June 15, 2011

26.0K

Area of Science:

  • Biochemistry
  • Neuroscience
  • Genetics

Background:

  • Post-translational modifications (PTMs) are crucial for protein structure and function in all life forms.
  • Schizophrenia is a complex brain disorder with numerous genetic and environmental risk factors, but its underlying mechanisms are not fully understood.

Purpose of the Study:

  • To investigate the role of PTMs in the dysregulated pathways associated with schizophrenia.
  • To identify novel therapeutic targets by exploring PTMs in schizophrenia.

Main Methods:

  • Analysis of PTMs in various biological samples including cell lines, animal models, postmortem brain tissue, blood, plasma, and cerebrospinal fluid.
  • Utilizing PTMomics to study differential expression of PTMs in schizophrenia-related pathways.

Main Results:

  • Several PTMs have been found to be differentially expressed in pathways dysregulated in schizophrenia.
  • Evidence of PTM involvement in schizophrenia pathogenesis observed across diverse biological models and fluids.

Conclusions:

  • PTMs play a significant role in the molecular pathology of schizophrenia.
  • Unexplored pathways offer promising avenues for understanding schizophrenia and developing future treatments.
  • PTMomics is a valuable approach for advancing schizophrenia research.