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Updated: Sep 2, 2025

Bridging the Bio-Electronic Interface with Biofabrication
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Engineered living bioassemblies for biomedical and functional material applications.

Carlos F Guimarães1, Fernando Soto2, Jie Wang2

  • 13B's Research Group, Research Institute on Biomaterials, Biodegradables and Biomimetics, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, Guimarães, Portugal; ICVS/3B's, PT Government Associate Laboratory, University of Minho, Braga/Guimarães, Portugal; Canary Center at Stanford for Cancer Early Detection, Bio-Acoustic MEMS in Medicine (BAMM) Laboratory, Department of Radiology, School of Medicine Stanford University, Palo Alto, CA 94304-5427, USA.

Current Opinion in Biotechnology
|August 5, 2022
PubMed
Summary
This summary is machine-generated.

Engineered living bioassemblies, built from biological parts, offer new medical models and precise event quantification. These bioassemblies also function as robots and construction materials, driving bioengineering innovation.

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Area of Science:

  • Bioengineering
  • Synthetic Biology
  • Biotechnology

Background:

  • Biofabrication enables the creation of complex biological constructs.
  • Engineered bioassemblies integrate biological or biosynthetic components.
  • These constructs have diverse applications in medicine and engineering.

Purpose of the Study:

  • To review advances in biofabrication of living bioassemblies.
  • To explore applications in medicine, including tunable biological models and event quantification.
  • To discuss non-biomedical applications and future bioengineering design principles.

Main Methods:

  • Review of current literature on biofabrication techniques.
  • Analysis of bottom-up assembly strategies for living entities.
  • Exploration of engineering principles for bioassembly design.

Main Results:

  • Bioassemblies offer tunable biological models for research.
  • Precise quantification of biological events is achievable.
  • Bioassemblies show potential as functional robots and construction materials.

Conclusions:

  • Living bioassemblies represent a significant advancement in bioengineering.
  • Future work should focus on design principles for next-generation applications.
  • Interdisciplinary approaches are crucial for overcoming challenges in the field.