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Updated: Sep 2, 2025

Cardiac Magnetic Resonance for the Evaluation of Suspected Cardiac Thrombus: Conventional and Emerging Techniques
Published on: June 11, 2019
Advanced cardiac imaging in the spectrum of COVID-19 related cardiovascular involvement
Anna Palmisano1, Michele Gambardella2, Tommaso D'Angelo3
1Experimental Imaging Center, IRCCS San Raffaele Scientific Institute, Via Olgettina 60, Milan, Italy; School of Medicine, Vita-Salute San Raffaele University, Via Olgettina 58, Milan, Italy.
Insights
COVID-19 commonly affects the heart, increasing risks. Advanced cardiac imaging like coronary CT angiography and Cardiac MRI are vital for diagnosing, monitoring, and assessing prognosis in patients with cardiovascular complications.
Area of Science:
- Cardiology
- Infectious Diseases
- Radiology
Background:
- Cardiovascular involvement is a frequent complication of COVID-19.
- This involvement is linked to a higher risk of adverse outcomes.
- SARS-CoV-2 infection can lead to endothelial and myocardial damage.
Purpose of the Study:
- To review the mechanisms of SARS-CoV-2-induced cardiovascular damage.
- To present the prognostic implications of this damage.
- To overview advanced cardiac imaging findings in COVID-19 patients.
Main Methods:
- Review of current knowledge on SARS-CoV-2 mechanisms and cardiovascular effects.
- Analysis of prognostic implications of COVID-19 related cardiovascular damage.
- Overview of findings from coronary CT angiography and Cardiac Magnetic Resonance imaging.
Main Results:
- SARS-CoV-2 can trigger endothelial and myocardial injury through various mechanisms.
- Cardiovascular damage significantly impacts patient prognosis.
- Advanced imaging reveals characteristic findings in acute, post-acute, and post-vaccination COVID-19 settings.
Conclusions:
- Advanced imaging modalities (CT angiography, CMR) are essential for managing COVID-19 patients with suspected cardiac involvement.
- These techniques aid in diagnosis, follow-up, and risk stratification.
- Understanding imaging findings is crucial for clinical decision-making.
Abstract:
Cardiovascular involvement is a common complication of COVID-19 infection and is associated to increased risk of unfavorable outcome. Advanced imaging modalities (coronary CT angiography and Cardiac Magnetic Resonance) play a crucial role in the diagnosis, follow-up and risk stratification of patients affected by COVID-19 pneumonia with suspected cardiovascular involvement. In the present manuscript we firstly review current knowledge on the mechanisms by which SARS-CoV-2 can trigger endothelial and myocardial damage. Secondly, the implications of the cardiovascular damage on patient's prognosis are presented. Finally, we provide an overview of the main findings at advanced cardiac imaging characterizing COVID-19 in the acute setting, in the post-acute syndrome, and after vaccination, emphasizing the potentiality of CT and CMR, the indication and their clinical implications.
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