Age-related hearing loss in BDF1 mice as evidenced by the brainstem auditory evoked potential

Age-related hearing loss was studied in unanesthetized female BDF1 mice using brainstem auditory evoked potential (BAEP) latency-intensity (L-I) profiles and BAEP thresholds. The mice were divided into 5 age-related groups: 3-4 months, 5.5-7 months, 9-10 months, 12 months and 18 months. Relative to the youngest group, BAEP threshold data indicated shifts in auditory sensitivity ranging from +6 dB for the 5.5- to 7-month-old group to +71 dB for the 18-month-old group. The BAEP L-I profiles of older mice were consistent with recruitment-type sensorineural (cochlear) hearing losses. No evidence of retrocochlear involvement was observed.