Related Experiment Video
Updated: Sep 2, 2025

Analysis of Human T Cell Activity in an Allogeneic Co-Culture Setting of Pre-Treated Tumor Cells
Published on: March 7, 2025
Immune checkpoint blockade provokes resident memory T cells to eliminate head and neck cancer
Joshua R Veatch1, Stanley R Riddell1
1Fred Hutchinson Cancer Center, Seattle, WA 98109, USA.
Abstract:
Immune checkpoint blockade is effective in treating many human cancers. In this issue of Cell, Luoma et al. show that tissue-resident memory T cells in head and neck cancers rapidly respond to immune checkpoint blockade, and they identify specific CD8+ T cells in pretreatment blood that predict pathologic tumor regression.
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