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Gestational phthalate exposure and lung function during childhood: A prospective population-based study.

Magda Bosch de Basea1, Anne-Elie Carsin2, Alicia Abellan3

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Environmental Pollution (Barking, Essex : 1987)
|August 5, 2022
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Summary

Gestational exposure to phthalates may negatively impact children's lung function, specifically reducing forced vital capacity (FVC) and forced expiratory volume (FEV1). This association was observed throughout childhood, particularly in early years, highlighting the need for phthalate exposure regulations.

Keywords:
Child healthGestational exposureLung functionPhthalates

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Area of Science:

  • Environmental Health
  • Pediatric Pulmonology
  • Toxicology

Background:

  • Phthalate exposure during pregnancy is widespread.
  • The impact of prenatal phthalate exposure on childhood lung function remains unclear.
  • Phthalates are known endocrine disruptors with potential health implications for children.

Purpose of the Study:

  • To investigate the association between gestational phthalate exposure and lung function in children from ages 4 to 11.
  • To assess phthalate effects on forced vital capacity (FVC) and forced expiratory volume in 1 second (FEV1) over time.
  • To evaluate individual and mixture effects of phthalate metabolites on respiratory health.

Main Methods:

  • Measured 9 phthalate metabolites in urine from 641 pregnant women (INMA study, Spain).
  • Assessed offspring lung function (FVC, FEV1, FEV1/FVC) at ages 4, 7, 9, and 11.
  • Employed linear regression, mixed-effects models, and Weighted Quantile Sum (WQS) regression for statistical analysis.

Main Results:

  • Gestational phthalate exposure was consistently linked to lower FVC and FEV1 in children across all ages.
  • Specific phthalate metabolites like MEP, MiBP, MnBP, and MBzP showed statistically significant associations with reduced lung function.
  • WQS regression identified MBzP as a key contributor to the mixture effect of phthalates on lung function.

Conclusions:

  • Prenatal phthalate exposure is associated with diminished lung function (FVC and FEV1) in children, especially during early childhood.
  • Findings support the significance of phthalate metabolites like MEP, MiBP, MnBP, and MBzP in affecting respiratory development.
  • The results underscore the importance of current regulations limiting phthalate exposure due to their widespread presence and endocrine-disrupting properties.