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Related Experiment Videos

An environmentally-controlled extended-use small animal hypobaric chamber.

J A Devine, A Cymerman

    Aviation, Space, and Environmental Medicine
    |May 1, 1987
    PubMed
    Summary

    A new hypobaric chamber allows extended studies of small animals at simulated high altitudes. This controlled environment precisely manages pressure, temperature, and humidity for long-term research.

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    Area of Science:

    • Biomedical Engineering
    • Environmental Physiology
    • Animal Research Technology

    Background:

    • Studying the long-term physiological effects of low barometric pressure on small animals requires specialized equipment.
    • Existing equipment may lack precise environmental control or capacity for extended exposures.

    Purpose of the Study:

    • To design and describe an environmentally-controlled hypobaric chamber for extended small animal studies.
    • To enable research on the physiological impacts of simulated high-altitude conditions over prolonged periods.

    Main Methods:

    • A rectangular aluminum and acrylic chamber (3.3 x 10^5 cm^3) was constructed.
    • A computer/data acquisition unit controlled pressure, temperature (0-100°C), and relative humidity (20-80%).
    • Altitude simulation utilized a two-stage vacuum pump, with pressure regulated via a throttling valve.

    Main Results:

    • The chamber successfully maintained controlled low barometric pressures for extended durations.
    • Precise regulation of temperature, relative humidity, oxygen, and carbon dioxide levels was achieved.
    • The system allowed for sustained operations essential for long-term animal studies.

    Conclusions:

    • The developed hypobaric chamber provides a reliable platform for investigating the effects of simulated altitude on small animals.
    • This technology facilitates long-term physiological research under controlled hypobaric conditions.
    • The chamber's environmental controls are crucial for the validity of extended exposure studies.

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