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Engineering gold nanoparticles for molecular diagnostics and biosensing.

Beatriz B Oliveira1,2, Daniela Ferreira1,2, Alexandra R Fernandes1,2

  • 1UCIBIO, Departamento de Ciências da Vida, Faculdade de Ciências e Tecnologia, Universidade NOVA de Lisboa, Caparica, Portugal.

Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology
|August 6, 2022
PubMed
Summary
This summary is machine-generated.

Gold nanoparticles (AuNPs) offer unique properties for biomedical applications. Their use in biodetection and diagnostics, including biosensors, is rapidly advancing for improved healthcare outcomes.

Keywords:
biodetectionbioimagingdiagnosticsgold nanoparticlesnanomedicine

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Area of Science:

  • Biomedical Nanotechnology
  • Diagnostic Tools
  • Nanoparticle-Based Sensing

Background:

  • Nanotechnology advances enable engineered nanomaterials for biomedicine.
  • Gold nanoparticles (AuNPs) are of significant interest due to their unique properties.

Purpose of the Study:

  • To discuss the properties, synthesis, and conjugation of AuNPs.
  • To review current trends in AuNP applications for biomedical sensing and diagnostics.

Main Methods:

  • Review of properties of gold nanoparticles.
  • Discussion of synthesis and surface functionalization techniques.
  • Analysis of current trends in sensing and detection.

Main Results:

  • AuNPs possess tunable size, shape, and surface properties.
  • AuNPs exhibit favorable optical, electronic, and physicochemical features.
  • AuNPs are valuable for biodetection, diagnostics, molecular sensing, photoimaging, and biosensors.

Conclusions:

  • Gold nanoparticles are versatile tools in biomedical diagnostics.
  • Their applications span in vitro and in vivo nanodiagnostics and imaging.
  • Continued development promises enhanced biosensing capabilities.