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Corticogenesis across species at single-cell resolution.

Seon Hye E Park1, Ana K Ortiz1, Genevieve Konopka1

  • 1Department of Neuroscience, UT Southwestern Medical Center, Dallas, Texas, USA.

Developmental Neurobiology
|August 6, 2022
PubMed
Summary

Single-cell technologies are revolutionizing neurodevelopment research, enabling detailed studies of neocortex development across species. This review explores how these advancements illuminate cellular mechanisms, gene regulation, and future applications in corticogenesis.

Keywords:
basal radial gliacortexevolutiongenomicssingle cell

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Area of Science:

  • Developmental Neuroscience
  • Genomics
  • Cell Biology

Background:

  • The neocortex exhibits diverse, species-specific cell types organized during development.
  • Transient cell types contribute to permanent, evolved cortical features.
  • Understanding cellular and molecular mechanisms of corticogenesis is crucial.

Purpose of the Study:

  • To review single-cell genomics techniques applied to corticogenesis.
  • To summarize findings on cellular and molecular mechanisms driving neocortical development.
  • To examine epigenomic and posttranscriptional regulation in corticogenesis.

Main Methods:

  • Review of primary publications and in-depth review articles.
  • Focus on studies utilizing single-cell genomics and multi-omics technologies.
  • Analysis across gyrencephalic (primate) and lissencephalic (mouse, reptile, songbird) species.

Main Results:

  • Single-cell technologies enable interrogation of progenitor proliferation, lineage progression, neuronal specification, and arealization.
  • Recent studies reveal insights into epigenomic and posttranscriptional regulation of corticogenesis.
  • Advancements allow high-resolution understanding of species-specific cortical development.

Conclusions:

  • Single-cell and multi-omics technologies are powerful tools for studying neurodevelopment.
  • These methods provide unprecedented cellular and molecular resolution of corticogenesis.
  • Future applications promise deeper insights into brain evolution and function.