The impact of GPS-derived activity spaces on personal PM_2.5 exposures in the MADRES cohort

In-utero exposure to particulate matter with aerodynamic diameter less than 2.5 μm (PM_2.5) is associated with low birth weight and health risks later in life. Pregnant women are mobile and locations they spend time in contribute to their personal PM_2.5 exposures. Therefore, it is important to understand how mobility and exposures encountered within activity spaces contribute to personal PM_2.5 exposures during pregnancy.

We collected 48-h integrated personal PM_2.5 samples and continuous geolocation (GPS) data for 213 predominantly Hispanic/Latina pregnant women in their 3^rd trimester in Los Angeles, CA. We also collected questionnaires and modeled outdoor air pollution and meteorology in their residential neighborhood. We calculated three GPS-derived activity space measures of exposure to road networks, greenness (NDVI), parks, traffic volume, walkability, and outdoor PM_2.5 and temperature. We used bivariate analyses to screen variables (GPS-extracted exposures in activity spaces, individual characteristics, and residential neighborhood exposures) based on their relationship with personal, 48-h integrated PM_2.5 concentrations. We then built a generalized linear model to explain the variability in personal PM_2.5 exposure and identify key contributing factors.

Indoor PM_2.5 sources, parity, and home ventilation were significantly associated with personal exposure. Activity-space based exposure to roads was associated with significantly higher personal PM_2.5 exposure, while greenness was associated with lower personal PM_2.5 exposure (β = -3.09 μg/m³ per SD increase in NDVI, p-value = 0.018). The contribution of outdoor PM_2.5 to personal exposure was positive but relatively lower (β = 2.05 μg/m³ per SD increase, p-value = 0.016) than exposures in activity spaces and the indoor environment. The final model explained 34% of the variability in personal PM_2.5 concentrations.

Our findings highlight the importance of activity spaces and the indoor environment on personal PM_2.5 exposures of pregnant women living in Los Angeles, CA. This work also showcases the multiple, complex factors that contribute to total personal PM_2.5 exposure.