Related Experiment Video

Updated: Sep 2, 2025

A Novel Digital Platform for a Monitored Home-based Cardiac Rehabilitation Program
04:24

A Novel Digital Platform for a Monitored Home-based Cardiac Rehabilitation Program

Published on: April 19, 2019

11.7K

Cognitive decline in heart failure: Biomolecular mechanisms and benefits of exercise

Abdulbaset Maroofi1, Tatiana Moro2, Jacopo Agrimi2

  • 1Department of Exercise Physiology, Faculty of Physical Education & Sport Sciences, University of Guilan, Rasht, Iran.

Biochimica Et Biophysica Acta. Molecular Basis of Disease
|August 6, 2022
PubMed

Insights

Heart failure (HF) impairs cognitive function due to reduced blood flow and complex heart-brain signaling. Exercise may offer a protective strategy against this cognitive decline in HF patients.

Area of Science:

  • Cardiology
  • Neurology
  • Exercise Physiology

Background:

  • Heart failure (HF) affects systemic organ function, including the brain.
  • Reduced cardiac output in HF leads to cognitive impairment and reduced daily activity capacity.
  • A complex, bidirectional relationship exists between the heart and brain, involving hemodynamics, bioelectric, and endocrine signaling.

Purpose of the Study:

  • To explore known and hypothetical mechanisms by which exercise may prevent cognitive dysfunction in heart failure.
  • To highlight the need for a deeper understanding of cardio-cerebral interactions in HF.
  • To inform more effective prevention and treatment strategies for HF-related cognitive decline.

Main Methods:

  • Review of existing literature on heart failure, cognitive function, and exercise.
  • Analysis of physiological and signaling pathways connecting cardiac and cerebral health.
  • Exploration of potential exercise-based interventions for cardio-cerebral health.

Main Results:

  • Heart failure significantly impacts cognitive capacity through impaired hemodynamics and intricate signaling pathways.
  • Exercise presents a potential avenue for mitigating cognitive deficits associated with various forms of heart failure.
  • Further research is required to fully elucidate the mechanisms underlying exercise's cardioprotective and neuroprotective effects.

Conclusions:

  • Understanding the mechanisms of exercise's benefits is crucial for developing targeted interventions.
  • Enhanced knowledge of heart-brain interactions in HF can lead to improved patient outcomes.
  • Exercise may serve as a vital preventive and therapeutic tool for maintaining cognitive health in individuals with heart failure.

Keywords:
BDNFCerebral blood flowCognitive dysfunctionExercise trainingHeart failureHeart-brain axis

More Related Videos

Orienteering as a Tool for Cognitive Research: An Implementation Guide07:13

Orienteering as a Tool for Cognitive Research: An Implementation Guide

Published on: November 29, 2024

884
Getting to Compliance in Forced Exercise in Rodents: A Critical Standard to Evaluate Exercise Impact in Aging-related Disorders and Disease10:19

Getting to Compliance in Forced Exercise in Rodents: A Critical Standard to Evaluate Exercise Impact in Aging-related Disorders and Disease

Published on: August 22, 2014

14.3K

Related Concept Videos

Heart Failure II: Pathophysiology01:29

Heart Failure II: Pathophysiology

Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
31
Exercise and Cardiovascular Response01:20

Exercise and Cardiovascular Response

Exercise significantly impacts cardiovascular response, which is crucial for understanding patient health and designing effective treatment plans.
Light to moderate physical activity initiates a series of interconnected responses in the body. The heart rate modestly increases in anticipation of the workout, followed by widespread vasodilation as oxygen consumption by skeletal muscles increases. This results in decreased peripheral resistance, increased capillary blood flow, and accelerated...
1.1K
Exercise and Cardiac Output01:17

Exercise and Cardiac Output

Regular physical activity is essential for maintaining cardiovascular health, with aerobic exercises being particularly effective. According to the American Heart Association, 150 minutes of moderate to intense aerobic exercise per week is recommended for a healthy heart. Aerobic activities may include brisk walking, running, bicycling, cross-country skiing, and swimming, ideally performed three to five times per week.
Sustained exercise increases the muscles' oxygen demand, which can be...
1.3K
Pathophysiology of Heart Failure01:17

Pathophysiology of Heart Failure

Heart failure (HF) is a progressive syndrome involving ventricles that leads to inadequate cardiac output. It can be classified based on location and output or ejection fraction. Ejection fraction (EF) is an essential measurement in the diagnosis and surveillance of HF. Reduced EF corresponds to systolic heart failure (HFrEF). However, HF with preserved ejection fraction (HFpEF) is becoming increasingly prevalent. Also known as diastolic HF, this form of HF is related to aging. The...
1.8K
Heart Failure Drugs: Inhibitors of Renin-Angiotensin System01:26

Heart Failure Drugs: Inhibitors of Renin-Angiotensin System

The activation of the sympathetic nervous system and the renin-angiotensin-aldosterone system (RAAS) contributes to cardiac remodeling, and inhibiting the RAAS is a pharmacological target in heart failure management. As a result, neurohumoral modulation is a crucial treatment principle for managing heart failure. This approach involves using medications like ACE inhibitors (ACEIs), angiotensin receptor blockers (ARBs), β-blockers, mineralocorticoid receptor antagonists (MRAs), and neutral...
497
Heart Failure V: Medical Management01:30

Heart Failure V: Medical Management

Medical Management of Acute Decompensated Heart Failure (ADHF)The primary goals of therapy for patients hospitalized with acute decompensated heart failure (ADHF) include:Relieving symptomsOptimizing volume statusSupporting oxygenation and ventilationMaintaining cardiac output (CO) and end-organ perfusionIdentifying and addressing the cause of ADHFPreventing complicationsProviding patient education on factors precipitating HF exacerbationPlanning for dischargeOngoing monitoring and assessment...
23