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A Post-Neurosurgical Infection due to KPC-Producing Klebsiella pneumoniae Treated with Meropenem-Vaborbactam: A Case

Seohyun Choi1, Marianna Fedorenko2, Janet Lin-Torre3

  • 1School of Pharmacy, University of Washington, Seattle, USA.

International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases
|August 6, 2022
PubMed

Insights

This case report details a post-neurosurgical infection caused by carbapenemase-producing Klebsiella pneumoniae. Meropenem-vaborbactam monotherapy successfully cleared bacteremia, offering a potential treatment option for this challenging infection.

Area of Science:

  • Infectious Diseases
  • Microbiology
  • Pharmacology

Background:

  • Post-neurosurgical infections pose significant clinical challenges.
  • Carbapenemase-producing Klebsiella pneumoniae (CRKP) infections are associated with high morbidity and mortality.
  • Limited evidence exists for effective antibiotic treatment of CRKP bacteremia.

Observation:

  • A patient presented with post-neurosurgical infection and bacteremia.
  • The causative pathogen was identified as Klebsiella pneumoniae carbapenemase-producing Klebsiella pneumoniae.
  • The patient's clinical course and microbiological data were monitored.

Findings:

  • The patient received meropenem-vaborbactam (MEV) monotherapy.
  • MEV treatment was associated with successful clearance of bacteremia.
  • This suggests MEV as a potential therapeutic option for CRKP infections.

Implications:

  • Meropenem-vaborbactam monotherapy may be effective in treating CRKP bacteremia.
  • This case provides valuable clinical data for managing difficult-to-treat Gram-negative infections.
  • Further research is warranted to confirm the efficacy and safety of MEV in similar cases.
Keywords:
Carbapenem-resistant enterobacteralesCentral nervous systemKlebsiella pneumoniae carbapenemaseMeropenem-vaborbactamPost-neurosurgical

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