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Bone Remodeling

Bone Remodeling

Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.

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Injectable mesoporous bioactive nanoparticles regenerate bone tissue under osteoporosis conditions.

D Arcos¹, N Gómez-Cerezo¹, M Saiz-Pardo²

¹Departamento de Química en Ciencias Farmacéuticas, Facultad de Farmacia, Universidad Complutense de Madrid, Instituto de Investigación Sanitaria Hospital 12 de Octubre i+12, Plaza Ramón y Cajal s/n, 28040 Madrid, Spain; CIBER de Bioingeniería, Biomateriales y Nanomedicina, CIBER-BBN, 28040 Madrid, Spain.

Acta Biomaterialia

|August 6, 2022

Summary

Injectable mesoporous bioactive nanoparticles promote bone regeneration in osteoporotic rabbits. Loaded with ipriflavone, they enhance osteoblast presence and angiogenesis, offering a minimally invasive treatment for osteoporotic bone defects.

Keywords:

Bone regeneration Hyaluronic acid Ipriflavone Mesoporous bioactive nanoparticles Osteoporosis

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Biological Compatibility Profile on Biomaterials for Bone Regeneration

Published on: November 16, 2018

Area of Science:

Biomaterials Science
Nanotechnology
Regenerative Medicine

Background:

Mesoporous bioactive nanoparticles (MBNPs) show promise for bone regeneration.
Osteoporosis presents challenges for bone healing.
An injectable delivery system is needed for bone defect treatment.

Purpose of the Study:

To evaluate the in vivo osteogenic capability of MBNPs in an osteoporotic rabbit model.
To assess the effect of incorporating the anti-osteoporotic drug ipriflavone.
To develop an injectable MBNP-hydrogel system for intraosseous delivery.

Main Methods:

MBNPs synthesized via a double template method, loaded with ipriflavone.
In vitro assessment of inflammatory gene expression in macrophages.
Intraosseous injection of MBNP-hyaluronic acid hydrogel into bone defects in osteoporotic rabbits.
Histological analysis of bone regeneration and cellular response.

Main Results:

MBNPs demonstrated osteogenic capability and a moderate inflammatory response in vivo.
Ipriflavone-loaded MBNPs enhanced osteoblast presence and angiogenesis.
No significant difference in new bone formation was observed between groups.
The injectable hydrogel system was successfully delivered intraosseously.

Conclusions:

Injectable MBNPs promote bone regeneration in osteoporotic conditions.
Drug incorporation (ipriflavone) improves cellular response and vascularization.
This injectable system offers a minimally invasive approach for treating osteoporotic bone defects.