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Updated: Sep 2, 2025

Author Spotlight: Three-Dimensional Cephalometric Landmark Annotation Demonstration on Human Cone Beam Computed Tomography Scans
Published on: September 8, 2023
Comparison between a human judge and automatic landmark identification on digital models.
Nora Dolatabadi1, Robert L Boyd2, Heesoo Oh2
1Private practice, New York, NY.
This study found that specialized software for automatic landmark location in dental scans is highly reliable and accurate. The software
Area of Science:
- Biomedical image analysis
- Dental imaging technology
- Orthodontic diagnostics
Background:
- Accurate landmark identification is crucial for reliable biomedical image analysis.
- Orthodontic study models are essential for diagnosis, treatment planning, and record-keeping.
- Evaluating automated tools for landmark location in dental imaging is necessary.
Purpose of the Study:
- To assess the reliability and validity of a software program for automatic landmark identification.
- To compare software-based landmark location with human expert identification in orthodontic models.
Main Methods:
- Digital intraoral scans of 10 dental arches were analyzed.
- Four calibrated judges manually identified landmarks (cusp tips, interproximal contacts).
- Software automatically identified the same landmarks; agreement was assessed using statistical analysis (ICC, Bland-Altman plots).
Main Results:
- Excellent intraclass correlation coefficients (ICC) were found between software and human judges for x, y, and z coordinates (1.0, 1.0, 0.98).
- Regression analysis and Bland-Altman plots indicated no systematic errors in landmark identification.
- Software-based landmark identification demonstrated high agreement with human expert identification.
Conclusions:
- The automatic landmark location software is highly accurate and reliable.
- The software's performance is nearly identical to that of human judges.
- The software and human landmark identification methods are interchangeable for orthodontic applications.
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