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Related Experiment Video

Updated: Sep 2, 2025

Optical Trapping of Nanoparticles
13:39

Optical Trapping of Nanoparticles

Published on: January 15, 2013

22.5K

Optical trapping and manipulation for single-particle spectroscopy and microscopy.

Zhenzhen Chen1, Zhewei Cai2, Wenbo Liu1

  • 1Department of Applied Physical Sciences, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA.

The Journal of Chemical Physics
|August 6, 2022
PubMed
Summary

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Optical tweezers enable precise manipulation of colloidal particles, advancing nanoscale single-particle spectroscopy and microscopy. These optically trapped nanoprobes offer new ways to sense environments and study biological interactions.

Area of Science:

  • Physics, Optics
  • Nanotechnology
  • Biophysics

Background:

  • Optical tweezers offer precise control over microscopic particle position and orientation in solution.
  • Nanoscale single-particle spectroscopy and microscopy present significant challenges.
  • Functional nanoparticles can act as freestanding nanoprobes when optically trapped.

Purpose of the Study:

  • To describe the optical forces behind optical trapping and manipulation.
  • To review spectroscopy and microscopy techniques combined with optical tweezers.
  • To discuss challenges and opportunities in nanoparticle spectroscopy and microscopy using optical tweezers.

Main Methods:

  • Explanation of optical forces utilized in optical trapping.
  • Review of integrated spectroscopy and microscopy techniques with optical tweezers.

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Related Experiment Videos

Last Updated: Sep 2, 2025

Optical Trapping of Nanoparticles
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Optical Trapping of Nanoparticles

Published on: January 15, 2013

22.5K
Optical Trap Loading of Dielectric Microparticles In Air
08:57

Optical Trap Loading of Dielectric Microparticles In Air

Published on: February 5, 2017

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Optical Trapping of Plasmonic Nanoparticles for In Situ Surface-Enhanced Raman Spectroscopy Characterizations
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Optical Trapping of Plasmonic Nanoparticles for In Situ Surface-Enhanced Raman Spectroscopy Characterizations

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  • Analysis of challenges and potential solutions for single-nanoparticle studies.

    • Main Results:

    • Detailed description of optical forces governing particle manipulation.
    • Comprehensive overview of combined optical tweezer-spectroscopy/microscopy applications.
    • Identification of key challenges in nanoscale measurements and potential future directions.

    Conclusions:

    • Optical tweezers are powerful tools for manipulating nanoparticles for advanced sensing.
    • Combining optical tweezers with various techniques unlocks new possibilities in nanoscience.
    • Addressing current challenges will expand the utility of optical tweezers in biological and material science research.