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Related Concept Videos

Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

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Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
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Stem Cell Culture01:17

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Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
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iPS Cell Differentiation01:22

iPS Cell Differentiation

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The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.
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Embryonic Stem Cells00:57

Embryonic Stem Cells

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Embryonic stem (ES) cells were first discovered in mice in 1981 by Martin Evans. In 1998, James Thomson identified a method to isolate embryonic stem cells from humans. Human embryonic stem cells (hESCs) are obtained from 3-5 day old embryos that remain unused after an in vitro fertilization procedure.
ES cells are grown in a culture medium where they can divide indefinitely, creating ES cell lines. Under certain conditions, ES cells can differentiate, either spontaneously into a variety of...
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EPS and iPS Cells in Disease Research01:21

EPS and iPS Cells in Disease Research

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Embryonic and induced pluripotent stem cells are excellent models for disease research because of their ability to self-renew and differentiate into most cell types. Somatic cells from a patient are isolated and reprogrammed into induced pluripotent stem cells or iPSCs. These iPSCs are later differentiated into the desired cell type, which mirrors the diseased cell of the patient. In this way, disease models have been created for investigating diseases such as Down syndrome, type I diabetes,...
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Induced Pluripotent Stem Cells01:06

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Stem cells are undifferentiated cells that divide and produce different cell types. Ordinarily, cells that have differentiated into a specific cell type are terminally differentiated; however, scientists have found a way to reprogram these mature cells so that they dedifferentiate and return to an unspecialized, proliferative state. These cells are pluripotent like embryonic stem cells—able to produce all cell types—and are called induced pluripotent stem cells (iPSCs).
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Updated: Sep 2, 2025

CRISPR/Cas9 Gene Editing of Hematopoietic Stem and Progenitor Cells for Gene Therapy Applications
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Stem cell-based therapy for human diseases.

Duc M Hoang1, Phuong T Pham2, Trung Q Bach3

  • 1Department of Research and Development, Vinmec Research Institute of Stem Cell and Gene Technology, Vinmec Healthcare System, Hanoi, Vietnam. v.duchm3@vinmec.com.

Signal Transduction and Targeted Therapy
|August 6, 2022
PubMed
Summary
This summary is machine-generated.

Stem cell therapies using human pluripotent stem cells (hPSCs) and mesenchymal stem cells (MSCs) show promise for treating various diseases. MSC origin influences their effectiveness in regenerative medicine applications.

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Area of Science:

  • Regenerative Medicine
  • Stem Cell Biology
  • Clinical Translation

Background:

  • Stem cell technology, including human pluripotent stem cells (hPSCs) and multipotent mesenchymal stem cells (MSCs), is a rapidly advancing field in regenerative medicine.
  • hPSCs can differentiate into all human cell types, while MSCs have multipotent differentiation potential and self-renewal capacity.
  • Current research explores diverse clinical applications of stem cells for previously untreatable conditions.

Purpose of the Study:

  • To review recent clinical applications of hPSCs and MSCs from various sources (bone marrow, adipose tissue, umbilical cord).
  • To discuss the influence of MSC tissue origin on their therapeutic efficacy in specific diseases.
  • To facilitate the translation of stem cell research into clinical practice.

Main Methods:

  • Literature review of recent advancements in stem cell therapy.
  • Analysis of clinical trial data for hPSC and MSC applications.
  • Discussion of the MSC tissue origin concept and its implications.

Main Results:

  • MSCs derived from bone marrow (BM-MSCs) show potential for neurological disorders.
  • Adipose tissue-derived MSCs (AT-MSCs) are promising for reproductive disorders and skin regeneration.
  • Umbilical cord-derived MSCs (UC-MSCs) show potential for pulmonary conditions and acute respiratory distress syndrome.

Conclusions:

  • Stem cell therapy offers new therapeutic avenues for a range of human diseases.
  • The origin of MSCs (BM, AT, UC) is a critical factor determining their suitability for specific clinical applications.
  • Further research into MSC origin-specific functions will accelerate regenerative medicine's clinical translation.