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Anti-virulent Disruption of Pathogenic Biofilms using Engineered Quorum-quenching Lactonases
Published on: January 1, 2016
Quorum sensing-based interactions among drugs, microbes, and diseases
Shengbo Wu1,2,3, Shujuan Yang1, Manman Wang1
1School of Chemical Engineering and Technology, Tianjin University, Tianjin, 300072, China.
Researchers developed a Quorum Sensing-based Drug-Microbe-Disease (QS-DMD) database to map interactions between drugs, microbes, and diseases. This tool aids in understanding personalized medicine and developing new therapies.
Area of Science:
- Microbiology
- Pharmacology
- Computational Biology
Background:
- Diseases are linked to microbial interactions with drugs, but drug targets are often unclear.
- Existing studies show links between drugs, microbes, and diseases, necessitating a method to analyze these interactions.
Purpose of the Study:
- To develop a systematic workflow for constructing a comprehensive Drug-Microbe-Disease database.
- To elucidate the intricate interactions between drugs, microbes, and diseases, particularly those mediated by Quorum Sensing.
Main Methods:
- Developed a three-module workflow to create the Quorum Sensing-based Drug-Microbe-Disease (QS-DMD) database.
- Employed docking-based virtual screening and in vitro validation to identify drug-microbe interactions targeting Quorum Sensing receptors.
- Constructed a QS-based drug-receptor interaction network and a drug-receptor-microbe-disease framework.
Main Results:
- Created the QS-DMD database, integrating over 8,000 drugs, 163 microbes, and 42 diseases.
- Identified potential interactions between thousands of drugs and microbes by targeting microbial Quorum Sensing receptors.
- Mapped a circular interaction network revealing QS-based mechanisms underlying drug-microbe-disease associations.
Conclusions:
- The QS-DMD database provides a valuable resource for understanding complex molecular interactions in human health.
- This work establishes a paradigm for building molecule-receptor-microbe-disease networks, crucial for precision medicine.
- The QS-DMD database will advance personalized medicine and therapeutic development for various diseases.
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