Related Experiment Video
Updated: Sep 2, 2025

Assessment of Gut Barrier Integrity in Mice Using Fluorescein-Isothiocyanate-Labeled Dextran
Published on: November 18, 2022
Relationship between intestinal hyperpermeability and obesity
László Ságodi1, Enikő Sólyom2, László Ságodi3
11 Miskolci Egyetem, Egészségügyi Kar, Preventív Egészségtudományi Tanszék Miskolc, Szentpéteri kapu 72-76., 3524 Magyarország.
Intestinal microbiota dysbiosis contributes to obesity by impairing the gut barrier, leading to inflammation. Restoring gut health can help manage obesity and related metabolic disorders.
Area of Science:
- Microbiology
- Immunology
- Metabolic Disorders
Background:
- Obesity involves genetic, environmental, and inflammatory factors.
- Intestinal microbiota is increasingly recognized as a key environmental factor in obesity.
- Microbiota dysbiosis is linked to metabolic disorders.
Purpose of the Study:
- To review the association between intestinal microbiota and obesity.
- To elucidate the mechanisms linking gut dysbiosis to obesity and inflammation.
Main Methods:
- Literature review of existing data on gut microbiota and obesity.
- Analysis of mechanisms involving gut barrier integrity and inflammation.
Main Results:
- Gut microbiota dysbiosis impairs gut barrier integrity and GALT development.
- Intestinal hyperpermeability allows LPS translocation, inducing adipose tissue inflammation.
- Chronic low-grade inflammation driven by gut dysbiosis contributes to obesity.
Conclusions:
- Intestinal microbiota plays a critical role in obesity development.
- Gut barrier dysfunction and inflammation are key pathways.
- Interventions targeting the gut barrier may help prevent and treat obesity.
More Related Videos
07:32An Intravital Microscopy-Based Approach to Assess Intestinal Permeability and Epithelial Cell Shedding Performance
Published on: December 3, 2020
09:24Functional Assessment of Intestinal Permeability and Neutrophil Transepithelial Migration in Mice using a Standardized Intestinal Loop Model
Published on: February 11, 2021
Related Concept Videos
Obesity
Glucose Absorption Into the Small Intestine
Factors Influencing Drug Absorption: Disease States and Pharmacology
Substances such as alcohol and specific drugs, including antineoplastics, can also negatively impact drug absorption. For instance,...
Transcellular Transport of Solutes
Anatomy of the Intestines
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...
Irritable Bowel Syndrome I: Introduction
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...