Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Complement activation by parasites. A review.

F Santoro, J Bernal, A Capron

    Acta Tropica
    |March 1, 1979
    PubMed
    Summary
    This summary is machine-generated.

    Parasite activation of the complement system can be lethal to parasites or essential for their survival. Both classical and alternative complement pathways are involved in host-parasite interactions.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    The interleukin 2 receptor in the hypereosinophilic syndrome.

    Leukemia & lymphoma·1992
    Same author

    Protection of mice and nude rats against toxoplasmosis by a multiple antigenic peptide construction derived from Toxoplasma gondii P30 antigen.

    Journal of immunology (Baltimore, Md. : 1950)·1992
    Same author

    Determination of B-cell epitopes of nef HIV-I protein: immunogenicity related to their structure.

    Molecular immunology·1992
    Same author

    Amino acid sequence requirements for the epitope recognized by a monoclonal antibody reacting with the secreted antigen GP28.5 of Toxoplasma gondii.

    Molecular immunology·1992
    Same author

    Fibronectin cleavage fragments provide a growth factor-like activity for the differentiation of Trypanosoma cruzi trypomastigotes to amastigotes.

    European journal of cell biology·1992
    Same author

    Antibodies in rheumatoid synovial fluids bind to a restricted series of protein antigens in rheumatoid synovial tissue.

    Arthritis and rheumatism·1992
    Same journal

    Corrigendum to "Effectiveness of Mosquito Repellents for Human: A Systematic Review of Human-Based Studies" [Acta Tropica 280 (2026) 108182].

    Acta tropica·2026
    Same journal

    Spatiotemporal dynamics of cutaneous leishmaniasis in Yucatán, México: retrospective analysis of cases diagnosed between 2015 and 2024.

    Acta tropica·2026
    Same journal

    Dose- and time-dependent dissemination of viable Leishmania amazonensis following experimental footpad infection in mice.

    Acta tropica·2026
    Same journal

    Mosquito fauna (Diptera: Culicidae) in an Atlantic Forest remnant urban park and report of Chikungunya virus RNA detection in sylvatic mosquitoes.

    Acta tropica·2026
    Same journal

    How much can mosquito population dynamics models inform entomological surveillance? Assessing the transferability of Aedes aegypti climate-driven models in Argentina.

    Acta tropica·2026
    Same journal

    ECOLOGICAL PREFERENCES AND DISTRIBUTION OF CAVE-DWELLING SAND FLIES (DIPTERA: PSYCHODIDAE) IN PAKISTAN.

    Acta tropica·2026
    See all related articles

    Area of Science:

    • Immunology
    • Parasitology
    • Host-Parasite Interactions

    Background:

    • Complement activation by parasites influences host-parasite relationships.
    • Complement activation can be detrimental or beneficial to parasite survival and development.
    • Both classical and alternative complement pathways are implicated.

    Purpose of the Study:

    • To investigate the role of complement activation in host-parasite interactions.
    • To elucidate the mechanisms by which parasites activate complement.
    • To understand the consequences of complement activation for both host and parasite.

    Main Methods:

    • In vitro experiments using living parasites or purified parasite antigens.
    • Analysis of complement pathway activation (classical and alternative).

    Related Experiment Videos

  • Assessment of parasite viability and parasitemia development.

    • Main Results:

    • Complement activation was frequently lethal to parasites in vitro.
    • In some cases, complement activation was essential for parasite development (parasitemia).
    • Parasites can activate both classical (antibody-dependent) and alternative (direct) complement pathways.
    • Alternative pathway activation can promote cellular adherence to parasites, leading to parasite death.

    Conclusions:

    • Complement activation is a critical factor in host-parasite dynamics.
    • Parasites can manipulate complement pathways for their own benefit or become victims of the host's immune response.
    • Understanding complement activation is key to developing strategies against parasitic infections.