Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Protein Complex Assembly

Protein Complex Assembly

Proteins can form homomeric complexes with another unit of the same protein or heteromeric complexes with different types. Most protein complexes self-assemble spontaneously via ordered pathways, while some proteins need assembly factors that guide their proper assembly. Despite the crowded intracellular environment, proteins usually interact with their correct partners and form functional complexes.
Many viruses self-assemble into a fully functional unit using the infected host cell to...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

The SNARE gene CwSYP121 enhances Ca²⁺ secretion and calcium tolerance of Ceratostigma willmottianum by modulating vesicle trafficking.

Plant science : an international journal of experimental plant biology·2026

Same author

Multicenter fine annotated surgical video dataset for minimally invasive glaucoma surgery.

Scientific data·2026

Same author

Classification of somatization symptoms based on latent profile analysis: The differential mediating role of psychological capital in organizational commitment.

Acta psychologica·2026

Same author

How self-efficacy influences Chinese university students' GenAI dependency: A study of the mediating roles of social anxiety and rumination and the moderating role of mindfulness.

Acta psychologica·2026

Same author

Effect of Nanotextured Stainless Steel Surface Features on Antibacterial Properties and Osteoblast Activity In Vitro.

Journal of biomedical materials research. Part A·2026

Same author

Microwave-Assisted Synthesis of PNA@AuNRs with Temperature Gating for Precise Amplification of Nucleic Acids.

Analytical chemistry·2026

Search research articles

Related Experiment Video

Updated: Sep 2, 2025

Rapid, Scalable Assembly and Loading of Bioactive Proteins and Immunostimulants into Diverse Synthetic Nanocarriers Via Flash Nanoprecipitation

Rapid, Scalable Assembly and Loading of Bioactive Proteins and Immunostimulants into Diverse Synthetic Nanocarriers Via Flash Nanoprecipitation

Published on: August 11, 2018

Self-assembling nanocarriers from engineered proteins: Design, functionalization, and application for drug delivery.

Yirui Li¹, Julie A Champion²

¹BioEngineering Program, Georgia Institute of Technology, United States.

Advanced Drug Delivery Reviews

|August 7, 2022

Summary

Engineered self-assembling proteins offer versatile platforms for creating novel drug nanocarriers. These custom-designed protein nanocarriers demonstrate significant potential for targeted drug delivery and therapeutic applications.

More Related Videos

Directed Assembly of Elastin-like Proteins into defined Supramolecular Structures and Cargo Encapsulation In Vitro

Directed Assembly of Elastin-like Proteins into defined Supramolecular Structures and Cargo Encapsulation In Vitro

Published on: April 8, 2020

Facile Preparation of Internally Self-assembled Lipid Particles Stabilized by Carbon Nanotubes

Facile Preparation of Internally Self-assembled Lipid Particles Stabilized by Carbon Nanotubes

Published on: February 19, 2016

Related Experiment Videos

Last Updated: Sep 2, 2025

Rapid, Scalable Assembly and Loading of Bioactive Proteins and Immunostimulants into Diverse Synthetic Nanocarriers Via Flash Nanoprecipitation

Rapid, Scalable Assembly and Loading of Bioactive Proteins and Immunostimulants into Diverse Synthetic Nanocarriers Via Flash Nanoprecipitation

Published on: August 11, 2018

Directed Assembly of Elastin-like Proteins into defined Supramolecular Structures and Cargo Encapsulation In Vitro

Directed Assembly of Elastin-like Proteins into defined Supramolecular Structures and Cargo Encapsulation In Vitro

Published on: April 8, 2020

Facile Preparation of Internally Self-assembled Lipid Particles Stabilized by Carbon Nanotubes

Facile Preparation of Internally Self-assembled Lipid Particles Stabilized by Carbon Nanotubes

Published on: February 19, 2016

Area of Science:

Biotechnology
Materials Science
Nanomedicine

Background:

Self-assembling proteins are advantageous for drug nanocarrier construction due to their self-assembly, monodispersity, biocompatibility, and biodegradability.
Genetic and chemical modifications enable modular design of protein nanocarriers for enhanced drug encapsulation, targeting, and responsiveness.

Purpose of the Study:

To review recent advancements in protein nanocarriers that are engineered from designed recombinant proteins, not natural protein structures.
To discuss the design, functionalization, and therapeutic applications of these novel protein nanocarriers.

Main Methods:

Review of literature on rationally or de novo designed recombinant protein self-assembly.
Analysis of protein nanocarriers complexed with other biomolecules.
Examination of therapeutic delivery of small molecules, proteins, and nucleic acids.

Main Results:

Engineered protein nanocarriers exhibit unique properties distinct from natural protein carriers.
Demonstrated in vitro and in vivo efficacy in delivering various therapeutic molecules.
Potential for tailored drug encapsulation, targeted delivery, stimuli-responsiveness, and extended in vivo half-life.

Conclusions:

Rationally designed self-assembling proteins represent a promising frontier in nanomedicine for advanced drug delivery systems.
These engineered protein nanocarriers offer tunable properties for diverse therapeutic strategies.