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Orientational cell adhesions (OCAs) for tissue morphogenesis.

Lili Zhang1, Xiangyun Wei2

  • 1Department of Psychology, Dalian Medical University, Dalian, Liaoning Province, 116044, China.

Trends in Cell Biology
|August 7, 2022
PubMed
Summary

Cells organize with specific orientations, guided by cell adhesion. We introduce orientational cell adhesions (OCAs) to link cell orientation and adhesion, providing a new view of tissue morphogenesis.

Keywords:
apicobasal cell polaritycell adhesioncellular patterningorientational cell adhesionplanar cell polaritytissue morphogenesis

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Area of Science:

  • Cell biology
  • Developmental biology
  • Biophysics

Background:

  • Tissue architecture is determined by the spatial arrangement of cells.
  • Intercellular relationships, including cell orientation, are crucial for tissue development.
  • Cell adhesions play a key role in maintaining these cellular arrangements.

Purpose of the Study:

  • To introduce the concept of 'orientational cell adhesions' (OCAs).
  • To link cell orientation with cell adhesion mechanisms.
  • To offer a novel perspective for studying tissue morphogenesis.

Main Methods:

  • Conceptual framework development.
  • Literature review on cell adhesion and tissue morphogenesis.
  • Theoretical modeling of cell-cell interactions.

Main Results:

  • Defined orientational cell adhesions (OCAs) as a unifying concept.
  • Established a link between cell orientation and the molecular mechanisms of cell adhesion.
  • Proposed OCAs as a critical factor in establishing tissue architecture.

Conclusions:

  • Orientational cell adhesions provide a new framework for understanding tissue morphogenesis.
  • This concept integrates cell orientation and cell adhesion for studying tissue development.
  • OCAs offer a novel perspective to investigate how distinct tissue architectures arise.