Chemerin fragments show different effects on systemic blood pressure dependent on carboxyl-terminal cleavage site

Area of Science:

• Endocrinology
• Neuroscience
• Cardiovascular Physiology

Background:

• Chemerin is an adipocytokine linked to elevated blood pressure.
• Previous research suggests chemerin's role in central blood pressure regulation.
• The in vivo effects of cleaved chemerin fragments remain largely unexplored.

Purpose of the Study:

• To investigate the in vivo effects of different mouse chemerin fragments on systemic blood pressure.
• To determine if specific C-terminal cleavage products of chemerin influence blood pressure regulation.

Main Methods:

• Acute intracerebroventricular (i.c.v.) administration of mouse chemerin-9, -8, and -7 fragments in Wistar rats.
• Cumulative administration of chemerin fragments at doses of 1-30 nmol/head.
• Systemic blood pressure measurement using a cannulation method under isoflurane anesthesia.

Main Results:

• Mouse chemerin-9 (mChemerin-9) induced a dose-dependent pressor response (increased blood pressure).
• Mouse chemerin-8 (mChemerin-8) and mouse chemerin-7 (mChemerin-7) did not significantly affect systemic blood pressure.
• The pressor effect of mChemerin-9 was observed at the highest doses administered.

Conclusions:

• Mouse chemerin-9, representing the C-terminal nine amino acids of active mouse chemerin, increases systemic blood pressure in rats.
• The study demonstrates that different C-terminal cleavage patterns of chemerin result in distinct in vivo effects on blood pressure.
• These findings contribute to understanding the central mechanisms of chemerin in blood pressure regulation.