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Efficacy and safety of omalizumab therapy in urticaria vasculitis
Fiorella Petrelli1, Daiana Giannini1, Silvia Bilia1
1Immunoallergology Unit, Department of Clinical and Experimental Medicine, Pisa University, Pisa, Italy.
Abstract:
Urticarial vasculitis (UV) is a small-vessel leukocytoclastic vasculitis characterized by different clinical manifestations ranging from long-lasting urticarial lesions to severe and potentially life-threatening multi-organ involvement. Omalizumab (OMA), anti-IgE recombinant humanized IgG1 monoclonal antibody, has been successfully used to treat few cases of severe and/or refractory UV. In this study we report our experience on 6 patients with refractory normocomplementemic UV successfully treated with anti-IgE therapy (OMA), suggesting that this biological therapy may be a safe and effective therapeutic option in UV.
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