Potential targets and treatments affect oxidative stress in gliomas: An overview of molecular mechanisms

Area of Science:

• Neuro-oncology
• Biochemistry
• Cellular Biology

Background:

• Oxidative stress arises from an imbalance between oxidation and antioxidant activity, involving reactive oxygen species (ROS).
• While ROS have protective roles, their excessive accumulation causes cellular damage and apoptosis.
• Gliomas, common central nervous system malignancies, exhibit altered redox states linked to increased free radicals and diminished antioxidant defenses.

Purpose of the Study:

• To review the role of oxidative stress in glioma pathogenesis.
• To identify potential therapeutic targets and drugs for glioma treatment based on oxidative stress.
• To analyze the impact of radiotherapy and chemotherapy on oxidative stress in gliomas.

Main Methods:

• Literature review of studies on oxidative stress and gliomas.
• Analysis of the relationship between redox state and glioma development.
• Evaluation of antioxidant therapies, radiotherapy, and chemotherapy in the context of oxidative stress.

Main Results:

• Oxidative stress is a critical factor in glioma development and progression.
• Altered redox balance, characterized by increased ROS and reduced antioxidants, is a hallmark of gliomas.
• Antioxidant-based strategies present a potential avenue for glioma treatment.

Conclusions:

• Oxidative stress plays a crucial role in the pathogenesis of gliomas.
• Targeting oxidative stress pathways offers a promising strategy for novel glioma therapies.
• Understanding the interplay between oxidative stress and conventional treatments can guide precise therapeutic interventions for gliomas.