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Assessment of Vascular Function in Patients With Chronic Kidney Disease
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Serum Endocan Levels and Subclinical Atherosclerosis in Patients with Chronic Kidney and End-Stage Renal Diseases

Fatma M El-Senosy1, Rasha Elsayed Mohamed Abd El Aziz2, Sammar Ahmed Kasim1

  • 1Department of Internal Medicine, Faculty of Medicine (Girls) Al-Azhar University, Cairo, Egypt.

International Journal of Clinical Practice
|August 8, 2022
PubMed

Insights

Elevated serum endocan levels are linked to cardiovascular issues in hemodialysis (HD) patients. Higher endocan indicates a greater risk of stroke and cardiovascular events in this population.

Area of Science:

  • Biochemistry
  • Nephrology
  • Cardiology

Background:

  • Endocan, a novel biomarker, is implicated in vascular inflammation and cardiovascular disease.
  • Chronic kidney disease (CKD) and hemodialysis (HD) are associated with increased cardiovascular risk.
  • The role of endocan in patients undergoing HD, particularly concerning cardiovascular events, requires further elucidation.

Purpose of the Study:

  • To investigate the association between serum endocan levels and cardiovascular events in patients with CKD and HD.
  • To evaluate endocan as a potential biomarker for stroke and cardiovascular events in HD patients.

Main Methods:

  • Serum endocan levels were measured in patients undergoing HD, CKD patients, and a control group.
  • Carotid intima-media thickness (CIMT) and the frequency of stroke and cardiovascular events (SCA) were assessed.
  • High-sensitivity C-reactive protein (hsCRP) levels were analyzed.
  • Receiver operating characteristic (ROC) curve analysis was performed to determine the diagnostic value of endocan.

Main Results:

  • HD and CKD groups exhibited significantly higher endocan levels than the control group, with HD patients showing the highest levels.
  • HD patients had significantly increased CIMT and a higher frequency of SCA compared to CKD patients.
  • Patients with SCA had markedly elevated hsCRP and endocan levels.
  • ROC analysis indicated that endocan, at a cutoff of 380.5 ng/L, could identify SCA in HD patients with 92.9% sensitivity and 68.7% specificity (AUC = 0.862).

Conclusions:

  • Serum endocan levels are significantly associated with stroke and cardiovascular events in hemodialysis patients.
  • Endocan may serve as a valuable biomarker for identifying patients at high risk of cardiovascular events in the context of HD.
  • The findings suggest a link between endocan, cardiovascular risk, and the hyperinflammatory state in HD patients.
Abstract

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