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Updated: Jul 26, 2026
13:08
Measurement of Factor V Activity in Human Plasma Using a Microplate Coagulation Assay
Published on: September 9, 2012
19.1K
A Combined Factor V and Factor VIII Deficiency: A Case Report
Ammar Kalas1, Abdelrahman Hassan1, Oumar Alkhalifa1
1College of Medicine, Sulaiman Al Rajhi University, Al Bukayriyah, SAU.
Cureus
|August 8, 2022
Summary
This case report highlights a rare combined deficiency of factor V and factor VIII (F5F8D) in a Saudi adolescent presenting with abdominal pain. Early consideration of this coagulopathy is crucial for accurate diagnosis and management.
Area of Science:
- Hematology
- Genetics
- Rare Diseases
Background:
- Factor V and VIII deficiency (F5F8D) is a rare, autosomal recessive coagulopathy.
- It is characterized by reduced activity of coagulation factors V and VIII.
Observation:
- A 15-year-old Saudi female presented with lower abdominal pain.
- Initial tests revealed low hemoglobin and prolonged activated partial thromboplastin time (aPTT), prothrombin time (PT), and international normalized ratio (INR).
Findings:
- Factor tests confirmed reduced activities of factor V and factor VIII, diagnosing combined F5F8D.
- The patient's symptoms were attributed to this rare bleeding disorder.
Implications:
- Combined deficiency of factors V and VIII should be considered in the differential diagnosis of patients with prolonged PT, INR, and aPTT.
- Medical management is indicated for patients experiencing significant bleeding events related to F5F8D.
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