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Quantitative Immunohistochemistry of the Cellular Microenvironment in Patient Glioblastoma Resections

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Alpha2beta1 Integrin Polymorphism in Diffuse Astrocytoma Patients.

Silvia A Teixeira^1,2, Regislaine V Burim^1,3, Mariano S Viapiano^4,5

¹Department of Surgery and Anatomy, Ribeirão Preto Medical School, University of São Paulo (USP), São Paulo, Brazil.

Frontiers in Oncology

|August 8, 2022

Summary

A specific genetic variation in the integrin alpha2beta1 (ITGA2) gene is linked to astrocytoma grade II. The ITGA2 genotype -/- correlates with poorer survival rates in astrocytoma patients.

Keywords:

ITGA2 brain microenvironment extracellular matrix invasion low grade glioma single nucleotide polymorphism tumor progression

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Area of Science:

Molecular Biology
Oncology
Genetics

Background:

Integrins, such as alpha2beta1 (α2β1), are transmembrane glycoproteins crucial for cell adhesion to the extracellular matrix.
Integrin signaling pathways influence glioma cell invasion and survival by altering the brain microenvironment.
The role of specific integrin genetic polymorphisms in astrocytoma development and progression requires further investigation.

Purpose of the Study:

To investigate the association between a single-nucleotide polymorphism (SNP) in the integrin alpha2beta1 (ITGA2) gene and the incidence and progression of diffusely infiltrating astrocytoma.
To explore the prognostic value of ITGA2 genotypes in astrocytoma patients.

Main Methods:

Genotyping of the ITGA2 single-nucleotide polymorphism in intron 7 using polymerase chain reaction and restriction enzyme analysis.
Analysis of ITGA2 genotype distribution in 158 astrocytoma patients and 162 controls.
In silico analysis of ITGA2 gene expression in low-grade gliomas (LGG) and glioblastomas (GBM) datasets.

Main Results:

The ITGA2 genotype +/+ (presence of BglII site) was more frequent in grade II astrocytoma patients compared to controls (P=0.02).
The ITGA2 genotype -/- (absence of BglII site) was associated with a significantly poorer survival rate (P=0.04).
Higher ITGA2 expression in LGG correlated with poor overall survival (P < 0.0001), but genotype distribution did not differ significantly between astrocytoma grades III and IV.

Conclusions:

A specific SNP in the ITGA2 gene shows a potential association with astrocytoma grade II and patient survival.
ITGA2 gene expression levels are linked to survival outcomes in low-grade gliomas.
Further research with larger cohorts is needed to confirm the prognostic significance of ITGA2 polymorphisms in astrocytoma.