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Amyloid Fibrils

Amyloid Fibrils

Amyloid fibrils are aggregates of misfolded proteins. Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils.
Amyloid deposits were observed as early as 1639 in the liver and the spleen. In 1854, Rudolph Virchow performed iodine staining,...

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Related Experiment Video

Updated: Sep 2, 2025

Imaging Amyloid Tissues Stained with Luminescent Conjugated Oligothiophenes by Hyperspectral Confocal Microscopy and Fluorescence Lifetime Imaging

Imaging Amyloid Tissues Stained with Luminescent Conjugated Oligothiophenes by Hyperspectral Confocal Microscopy and Fluorescence Lifetime Imaging

Published on: October 20, 2017

Unusual presentation in amyloidosis.

Ines Mahmoud¹, Leila Rouached¹, Meriem Chammakhi¹

¹Department of Rheumatology Charles Nicolle Hospital Tunis Tunisia.

Clinical Case Reports

|August 8, 2022

Summary

This summary is machine-generated.

This case study highlights amyloid arthropathy in a man with multiple myeloma, presenting as bone lesions and joint pain. Diagnosis was confirmed via salivary gland biopsy showing amyloid deposits.

Keywords:

amylois arthropathy biopsy multiple myeloma spine

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Last Updated: Sep 2, 2025

Imaging Amyloid Tissues Stained with Luminescent Conjugated Oligothiophenes by Hyperspectral Confocal Microscopy and Fluorescence Lifetime Imaging

Imaging Amyloid Tissues Stained with Luminescent Conjugated Oligothiophenes by Hyperspectral Confocal Microscopy and Fluorescence Lifetime Imaging

Published on: October 20, 2017

Performing and Processing FNA of Anterior Fat Pad for Amyloid

Performing and Processing FNA of Anterior Fat Pad for Amyloid

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Visualization of Amyloid β Deposits in the Human Brain with Matrix-assisted Laser Desorption/Ionization Imaging Mass Spectrometry

Visualization of Amyloid β Deposits in the Human Brain with Matrix-assisted Laser Desorption/Ionization Imaging Mass Spectrometry

Published on: March 7, 2019

Area of Science:

Rheumatology
Hematology
Pathology

Background:

Multiple myeloma can manifest with diverse extra-osseous complications.
Amyloid arthropathy is a rare manifestation of plasma cell dyscrasias.

Observation:

A 56-year-old male presented with osteolytic polyarthritis and an atlanto-axial lesion.
Initial presentation suggested advanced myeloma with skeletal involvement.

Findings:

Histological examination of a salivary gland biopsy revealed amyloid deposits.
Congo red staining confirmed the presence of amyloid, establishing the diagnosis of amyloid arthropathy.

Implications:

This case underscores the importance of considering amyloid arthropathy in multiple myeloma patients with polyarthritis.
Salivary gland biopsy can be a valuable diagnostic tool for amyloid deposition.
Early diagnosis of amyloid arthropathy is crucial for appropriate management and patient outcomes.