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Related Experiment Video

Updated: Sep 2, 2025

Activation of Apoptosis by Cytoplasmic Microinjection of Cytochrome c

Activation of Apoptosis by Cytoplasmic Microinjection of Cytochrome c

Published on: June 29, 2011

Mitochondrial sirtuin 3 and various cell death modalities.

Maria A Yapryntseva¹, Polina V Maximchik¹, Boris Zhivotovsky^1,2

¹Faculty of Basic Medicine, Lomonosov Moscow State University, Moscow, Russia.

Frontiers in Cell and Developmental Biology

|August 8, 2022

Summary

Sirtuin 3 regulates cell death and tumor metabolism. This review explores its role in eliminating cancer cells, focusing on mitochondria and reactive oxygen species (ROS).

Keywords:

cell death modalities mitochondria reactive oxygen species sirtuin tumor elimination

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Published on: July 17, 2018

Area of Science:

Cellular Biology
Biochemistry
Oncology

Background:

Sirtuin 3 is a mitochondrial NAD+-dependent deacetylase regulating cellular processes.
Key functions include managing oxidative stress, tumor cell metabolism, and homeostasis.
Sirtuin 3 influences mitochondrial outer membrane permeabilization, a critical step in apoptosis.

Purpose of the Study:

To review the role of Sirtuin 3 in tumor cell elimination.
To investigate the involvement of mitochondria and reactive oxygen species (ROS) in Sirtuin 3-mediated cancer cell death.

Main Methods:

Literature review focusing on Sirtuin 3's function in cell death pathways.
Analysis of studies linking Sirtuin 3 to mitochondrial function and ROS production in cancer.

Main Results:

Sirtuin 3 regulates mitochondrial outer membrane permeabilization, impacting apoptosis.
It plays a role in the crosstalk between different cell death modalities.
Sirtuin 3 is implicated in reprogramming tumor cell energy metabolism.

Conclusions:

Sirtuin 3 is a potential target for cancer therapy due to its role in tumor cell elimination.
Mitochondria and ROS are crucial mediators in Sirtuin 3's effects on cancer cells.
Further research into Sirtuin 3 could reveal new therapeutic strategies for cancer treatment.