Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Seminiferous tubule involution in elderly men.

R Paniagua, M Nistal, P Amat

    Biology of Reproduction
    |May 1, 1987
    PubMed
    Summary

    Aging human testes show progressive tubular involution, characterized by germ cell loss and morphological changes in seminiferous tubules. These changes, including Sertoli cell vacuolation and lipid accumulation, resemble effects seen after experimental ischemia.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Use of compounds naturally labeled with stable isotopes for the study of the metabolism of glycoprotein neutral sugars by gas-liquid chromatography-isotope-ratio mass spectrometry. Technical validation in the rat.

    Carbohydrate research·1992
    Same author

    Potent gp120-like neurotoxic activity in the cerebrospinal fluid of HIV-infected individuals is blocked by peptide T.

    Brain research·1992
    Same author

    Lateralized mediation of arousal and habituation: differential bilateral electrodermal activity in unilateral temporal lobectomy patients.

    Neuropsychologia·1992
    Same author

    Transfusion-associated graft-versus-host disease, monoclonal gammopathy and PCR.

    British journal of haematology·1992
    Same author

    What do patients want to know about their inflammatory bowel disease?

    The Italian journal of gastroenterology·1992
    Same author

    Phosphatidate phosphohydrolases in liver, heart and adipose tissue of the JCR:LA corpulent rat and the lean genotypes: implications for glycerolipid synthesis and signal transduction.

    International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity·1992

    Area of Science:

    • Reproductive Biology
    • Andrology
    • Gerontology

    Background:

    • Testicular aging involves progressive changes in seminiferous tubules.
    • Understanding these changes is crucial for male reproductive health in elderly men.

    Purpose of the Study:

    • To describe the stages and morphological characteristics of tubular involution in aging human testes.
    • To compare these age-related changes with effects of experimental ischemia.

    Main Methods:

    • Histological examination of seminiferous tubules from aging human testes.
    • Observation of morphological anomalies in germ cells and Sertoli cells.
    • Comparison with reported effects of experimental testicular ischemia.

    Main Results:

    • Aging testes exhibit a spectrum of tubular involution, from hypospermatogenesis to complete sclerosis.
    • Germ cell abnormalities include multinucleation and degeneration, leading to Sertoli cell vacuolation and lipid accumulation.
    • Tubular involution shows similarities to changes induced by experimental ischemia, suggesting common underlying mechanisms.

    Conclusions:

    • Testicular tubular involution is a progressive process in aging men.
    • Morphological changes observed in aging testes share similarities with ischemic injury.
    • Further research may elucidate specific mechanisms driving age-related testicular decline.

    Related Experiment Videos