Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Hindsight Biases01:12

Hindsight Biases

3.9K
Hindsight bias leads you to believe that the event you just experienced was predictable, even though it really wasn’t. In other words, you knew all along that things would turn out the way they did. Can you relate this to the phrase "Hindsight is 20/20" now? 
3.9K
Difference from Background: Limit of Detection01:05

Difference from Background: Limit of Detection

6.9K
The limit of detection (LOD) is the smallest amount of analyte that can be distinguished from the background noise. The LOD value corresponds to the concentration at which the analyte signal is three times larger than the standard deviation of the blank signal. Below this value, the analyte signal cannot be differentiated from the background noise. It is calculated by dividing the calibration slope by 3 times the standard deviation of the blank signals.
The LOD indicates the presence or absence...
6.9K
The Availability Heuristic01:08

The Availability Heuristic

6.3K
A heuristic is a general problem-solving framework (Tversky & Kahneman, 1974). You can think of these as mental shortcuts that are used to solve problems. Different types of heuristics are used in different types of situations, and the impulse to use a heuristic occurs when one of five conditions is met (Pratkanis, 1989):
6.3K
The Two-State Receptor Model01:29

The Two-State Receptor Model

2.1K
The two-state receptor model explains a drug's interaction with receptors, such as G protein-coupled receptors and ligand-gated ion channels, to induce or inhibit a biological response. When no natural ligands are present, a receptor exists in an equilibrium of inactive (Ri) and active (Ra) conformations. The inactive form does not produce a response, while the active form generates a basal effect known as constitutive activity.
The binding affinity of a drug determines its interaction with...
2.1K
¹H NMR: Interpreting Distorted and Overlapping Signals01:02

¹H NMR: Interpreting Distorted and Overlapping Signals

1.1K
Spin systems where the difference in chemical shifts of the coupled nuclei is greater than ten times J are called first-order spin systems. These nuclei are weakly coupled, and their chemical shifts and coupling constant can generally be estimated from the well-separated signals in the spectrum.
As Δν decreases and the signals move closer, the doublets appear increasingly distorted. The intensities of the inner lines increase at the cost of those of the outer lines as the signals are...
1.1K
Masking and Demasking Agents01:19

Masking and Demasking Agents

2.6K
EDTA titrations may necessitate masking and demasking agents to temporarily protect a particular metal ion in a mixture from the EDTA reaction. These agents facilitate the sequential analysis of the metal ions by forming stable complexes with some—but not all—metal ions during certain steps.
There are many masking agents, such as cyanide, fluoride, triethanolamine, thiourea, and 2,3-bis(sulfanyl)propan-1-ol (formerly 2,3-dimercapto-1-propanol), with the masking agent chosen based on...
2.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Discovering Genetic Variants in Hypertrophic Cardiomyopathy With Multiple Machine Learning Techniques.

IEEE transactions on computational biology and bioinformatics·2025
Same author

BN-BacArena: Bayesian network extension of BacArena for the dynamic simulation of microbial communities.

Bioinformatics (Oxford, England)·2024
Same author

Learning massive interpretable gene regulatory networks of the human brain by merging Bayesian networks.

PLoS computational biology·2023
Same author

NeuroSuites: An online platform for running neuroscience, statistical, and machine learning tools.

Frontiers in neuroinformatics·2023
Same author

Identifying Parkinson's disease subtypes with motor and non-motor symptoms via model-based multi-partition clustering.

Scientific reports·2021
Same author

Patient specific prediction of temporal lobe epilepsy surgical outcomes.

Epilepsia·2021
Same journal

Granular Ball-Based Noise-Resistant Fuzzy Multineighborhood Feature Selection via Label Enhancement and Feature Graph.

IEEE transactions on neural networks and learning systems·2026
Same journal

Fighting Evolving Spam With ARTMAP Models: A Noise-Resilient Online Detection Framework.

IEEE transactions on neural networks and learning systems·2026
Same journal

HyperSAT: Unsupervised Hypergraph Neural Networks for Weighted MaxSAT Problems.

IEEE transactions on neural networks and learning systems·2026
Same journal

Negation of Basic Belief Assignment in Multisource Information Fusion on Dempster-Shafer Theory With Applications in Pattern Classification.

IEEE transactions on neural networks and learning systems·2026
Same journal

Intervention Feasible Region and Driver Risk Capacity Aware Human-Machine Collaborative Safe Trajectory Planning.

IEEE transactions on neural networks and learning systems·2026
Same journal

A Unified Differential Denoising Learning Framework With a Pre-Trained Model and Fuzzy Graph Networks for Drug-Drug Interaction Prediction.

IEEE transactions on neural networks and learning systems·2026
See all related articles

Related Experiment Video

Updated: Sep 2, 2025

Author Spotlight: Enhancement of Salient Object Detection for Smart Grid Applications
03:31

Author Spotlight: Enhancement of Salient Object Detection for Smart Grid Applications

Published on: December 15, 2023

623

Feature Saliencies in Asymmetric Hidden Markov Models.

Carlos Esteban Puerto-Santana, Pedro Larranaga, Concha Bielza

    IEEE Transactions on Neural Networks and Learning Systems
    |August 8, 2022
    PubMed
    Summary
    This summary is machine-generated.

    This study introduces asymmetric hidden Markov models with feature saliencies for unsupervised feature selection in high-dimensional data. These models identify relevant features and probabilistic relationships, outperforming existing methods on synthetic and real-world datasets.

    More Related Videos

    Using Three-color Single-molecule FRET to Study the Correlation of Protein Interactions
    11:22

    Using Three-color Single-molecule FRET to Study the Correlation of Protein Interactions

    Published on: January 30, 2018

    10.2K
    Measuring Attention and Visual Processing Speed by Model-based Analysis of Temporal-order Judgments
    13:00

    Measuring Attention and Visual Processing Speed by Model-based Analysis of Temporal-order Judgments

    Published on: January 23, 2017

    10.0K

    Related Experiment Videos

    Last Updated: Sep 2, 2025

    Author Spotlight: Enhancement of Salient Object Detection for Smart Grid Applications
    03:31

    Author Spotlight: Enhancement of Salient Object Detection for Smart Grid Applications

    Published on: December 15, 2023

    623
    Using Three-color Single-molecule FRET to Study the Correlation of Protein Interactions
    11:22

    Using Three-color Single-molecule FRET to Study the Correlation of Protein Interactions

    Published on: January 30, 2018

    10.2K
    Measuring Attention and Visual Processing Speed by Model-based Analysis of Temporal-order Judgments
    13:00

    Measuring Attention and Visual Processing Speed by Model-based Analysis of Temporal-order Judgments

    Published on: January 23, 2017

    10.0K

    Area of Science:

    • Machine Learning
    • Data Science
    • Statistics

    Background:

    • Unsupervised learning often deals with high-dimensional, nonlabeled data, limiting feature selection options.
    • Existing feature saliency models for clustering typically assume variable independence, restricting their application.
    • There is a need for methods that can simultaneously perform feature selection and model probabilistic relationships in unsupervised settings.

    Purpose of the Study:

    • To introduce asymmetric hidden Markov models with feature saliencies (AHMM-FS) for unsupervised feature selection.
    • To enable simultaneous identification of relevant features and probabilistic variable relationships during model learning.
    • To compare the performance of AHMM-FS against state-of-the-art approaches.

    Main Methods:

    • Development of asymmetric hidden Markov models incorporating feature saliency.
    • Simultaneous learning of feature relevance and probabilistic dependencies between variables.
    • Evaluation using synthetic datasets and real-world data (grammatical face videos, ball bearing wear).

    Main Results:

    • The proposed AHMM-FS models demonstrate superior or comparable performance to existing state-of-the-art methods.
    • AHMM-FS effectively identifies relevant features in high-dimensional, nonlabeled data.
    • The models provide deeper insights into probabilistic relationships within the data.

    Conclusions:

    • AHMM-FS offers a robust solution for feature selection in unsupervised learning scenarios.
    • The models overcome the limitation of independence assumptions in previous feature saliency methods.
    • This approach enhances data analysis capabilities for complex, high-dimensional datasets.