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Published on: October 13, 2023
Tubarial gland involvement in IgG4-related diseases
Kenichi Takano1, Makoto Kurose1, Ryuta Kamekura1
1Department of Otolaryngology-Head and Neck Surgery, Sapporo Medical University, Sapporo, Japan.
Background:
Tubarial glands (TGs) are a collection of unidentified salivary glands overlying the torus tubarius in the nasopharyngeal wall. Immunoglobulin G4-related disease (IgG4-RD) is a chronic fibroinflammatory state that often has multiple organ involvement. Involvement of the head and neck, especially the salivary glands, is common in IgG4-RD.
Aims/Objectives:
This study aimed to elucidate the clinical significance of TGs in IgG4-RD.
Materials And Methods:
We investigated the local findings of TGs in ten patients with IgG4-RD.
Results:
Nasopharyngeal endoscopic examination revealed oedematous swelling of the nasopharyngeal wall surrounding the TGs, which improved after steroid treatment. Moreover, sonotubometry showed a stenotic pattern in three out of seven patients with IgG4-RD.
Conclusions And Significance:
TGs may be involved in IgG4-RD. The swollen TGs may be responsible for obstructive Eustachian tube dysfunction. Further studies are required to clarify the clinical significance and physiological roles of TGs in IgG4-RD.
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