Targeting endoplasmic reticulum stress using natural products in neurological disorders

Area of Science:

• Neuroscience
• Pharmacology
• Natural Products Chemistry

Background:

• Endoplasmic reticulum stress (ERS) is a key factor in the development of neurological conditions like Alzheimer's and Parkinson's disease.
• Understanding ERS pathways is crucial for developing new therapeutic strategies for neurodegenerative diseases.

Purpose of the Study:

• To review and synthesize existing literature on natural products that modulate endoplasmic reticulum stress (ERS).
• To explore the neuroprotective effects of these natural products in the context of various neurological disorders.

Main Methods:

• Comprehensive literature search of scientific databases including SCOPUS, PubMed, Web of Science, and Google Scholar.
• Analysis of studies investigating natural products targeting ERS signaling pathways.
• Evaluation of evidence for neuroprotective properties of identified natural products.

Main Results:

• Several natural products have demonstrated efficacy in targeting ERS pathways.
• These natural products exhibit significant neuroprotective potential against conditions such as cerebral ischemia, Parkinson's disease, and Alzheimer's disease.
• The review consolidates information on mechanisms of action and therapeutic applications.

Conclusions:

• Natural products offer promising therapeutic avenues for neurological disorders by mitigating ERS.
• Further research into these compounds could lead to novel neuroprotective treatments.
• Targeting ERS with natural products represents a viable strategy in neurodegenerative disease management.