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Related Experiment Video

Updated: Sep 2, 2025

Optimized Procedure for Determining the Adsorption of Phosphonates onto Granular Ferric Hydroxide using a Miniaturized Phosphorus Determination Method

Optimized Procedure for Determining the Adsorption of Phosphonates onto Granular Ferric Hydroxide using a Miniaturized Phosphorus Determination Method

Published on: May 18, 2018

Hypophosphatemia: A Practical Guide to Evaluation and Management.

Peter J Tebben¹

¹Division of Endocrinology, Departments of Pediatric and Adolescent Medicine and Internal Medicine, Mayo Clinic College of Medicine, Rochester, Minnesota.

Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists

|August 8, 2022

Summary

Phosphate is vital for skeletal health, energy, and cell function. This review covers phosphate balance, hypophosphatemia causes, and management strategies for optimal patient care.

Keywords:

fibroblast growth factor 23 hypophosphatemia osteomalacia rickets vitamin D

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Optimized Procedure for Determining the Adsorption of Phosphonates onto Granular Ferric Hydroxide using a Miniaturized Phosphorus Determination Method

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Published on: January 21, 2019

Area of Science:

Biochemistry
Human Physiology
Endocrinology

Background:

Phosphate is essential for skeletal mineralization, energy homeostasis, enzyme function, and cell membrane integrity.
Dysregulation of phosphate homeostasis can lead to various clinical manifestations.
Normal phosphate balance involves the gastrointestinal tract, bones, and kidneys.

Purpose of the Study:

To review normal phosphate homeostasis.
To discuss the clinical manifestations and causes of hypophosphatemia.
To outline an approach for diagnosing and managing hypophosphatemia.

Main Methods:

Literature review of phosphate metabolism and clinical hypophosphatemia.
Discussion of the roles of 1α,25-dihydroxyvitamin D3, parathyroid hormone, and fibroblast growth factor 23.
Synthesis of information on diagnostic and management strategies.

Main Results:

Phosphate's critical roles in physiology are highlighted.
Key systems regulating phosphate balance are identified.
The complex interplay of hormones in phosphate homeostasis is described.

Conclusions:

Understanding phosphate homeostasis is crucial for recognizing and treating hypophosphatemia.
A systematic approach to diagnosis and management is essential for patient outcomes.
Further research into phosphate regulation may yield novel therapeutic targets.