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Evolutionary Aspects of the Unfolded Protein Response

Kazutoshi Mori1

  • 1Department of Biophysics, Graduate School of Science, Kyoto University, Kyoto 606-8502, Japan.

Cold Spring Harbor Perspectives in Biology
|August 8, 2022
PubMed
Summary

The unfolded protein response (UPR) evolved with new sensors and regulators, enhancing endoplasmic reticulum (ER) homeostasis. These evolutionary changes, including PERK and ATF6 expansion, are crucial for vertebrate UPR complexity.

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