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Choroidal biopsies; a review and optimised approach.
R N Hussain1, B Damato2,3, H Heimann4
1Liverpool Ocular Oncology Centre, Royal Liverpool Hospital, Liverpool, L7 8XP, UK. rumanahussain@hotmail.com.
Eye (London, England)
|August 8, 2022
Summary
Choroidal biopsies aid diagnosis and prognostication of eye tumors, especially uveal melanoma. This review details techniques for accurate tumor sampling for histological and genetic analysis.
Area of Science:
- Ophthalmology
- Oncology
- Surgical Pathology
Background:
- Most choroidal tumors are accurately diagnosed using clinical examination and non-invasive imaging.
- Choroidal biopsies are valuable for diagnostic clarity in challenging cases, such as indeterminate lesions or identifying metastatic disease.
- Biopsy is increasingly used for prognostication in uveal melanoma.
Purpose of the Study:
- To review the indications for choroidal biopsies.
- To discuss surgical techniques for tumor acquisition.
- To present an optimized approach for improving histological and genetic analysis yield.
Main Methods:
- Review of current literature on choroidal biopsy indications and techniques.
- Description of surgical approaches for tumor sampling.
- Outline of an optimized protocol for enhanced diagnostic yield.
Main Results:
- Clinical examination and imaging suffice for most choroidal tumors.
- Biopsies are crucial for specific diagnostic dilemmas and prognostication.
- Optimized techniques improve the success rate of histological and genetic analysis.
Conclusions:
- Choroidal biopsies are essential tools for diagnosing and managing complex choroidal tumors.
- Accurate tumor sampling is critical for both histological subclassification and genetic profiling.
- The reviewed optimized approach enhances the utility of biopsies in clinical practice.
