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SIRT in 2025.

Francesca Romana Ponziani1, Francesco Santopaolo1, Alessandro Posa2

  • 1Dipartimento di Scienze Mediche e Chirurgiche, U.O.C. Medicina Interna e Gastroenterologia, Fondazione Policlinico Universitario, A. Gemelli IRCCS, L.go A. Gemelli 8, 00168, Rome, Italy.

Cardiovascular and Interventional Radiology
|August 8, 2022
PubMed
Summary
This summary is machine-generated.

Selective internal radiation therapy (SIRT) offers a minimally invasive treatment for liver cancer. Future applications in hepatocellular carcinoma involve combination therapies and new technologies for improved patient outcomes.

Keywords:
ChemotherapyHCCImmunotherapyLocoregional treatmentSIRTTARETKIYttrium-90

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Area of Science:

  • Oncology
  • Radiology
  • Hepatology

Background:

  • Selective internal radiation therapy (SIRT) is an endovascular treatment for primary liver malignancies.
  • Hepatocellular carcinoma (HCC) treatment varies by stage, with SIRT showing potential in early, intermediate, and advanced disease.

Purpose of the Study:

  • To review the future applications of SIRT in hepatocellular carcinoma.
  • To explore combination therapies, new devices, and technological advancements in SIRT for HCC.
  • To identify new potential indications and organizational perspectives for SIRT in liver cancer treatment.

Main Methods:

  • Literature review of existing studies on SIRT for liver malignancies.
  • Analysis of ongoing clinical trials investigating SIRT in hepatocellular carcinoma.
  • Evaluation of technological developments and new device applications in SIRT.

Main Results:

  • SIRT is a viable endovascular option for primary liver malignancies across various clinical stages.
  • Potential curative use in early-stage HCC and combination use in intermediate/advanced stages.
  • Future directions include combination with systemic treatments and novel technological integration.

Conclusions:

  • SIRT holds significant future promise for hepatocellular carcinoma treatment, especially in combination regimens.
  • Technological advancements and new devices will expand SIRT's applications and efficacy.
  • Further research and organizational development are crucial for optimizing SIRT's role in liver cancer care.