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Evaluation of cerium oxide as a phosphate binder using 5/6 nephrectomy model rat
Akiko Hashimoto1,2, Jiaqi Gao2, Yuki Kanome3
1applause Company Limited, Biko building 4F, Shinkawa 2-24-2, Chuo-ku, Tokyo, 104-0033, Japan.
BMC Nephrology
|August 8, 2022
Summary
Cerium oxide shows promise as a novel phosphate binder for chronic kidney disease (CKD) patients. This study demonstrated its ability to reduce serum phosphorus in a rat model without causing liver damage.
Area of Science:
- Nephrology
- Biochemistry
- Materials Science
Background:
- Chronic kidney disease (CKD) prevalence is rising globally.
- Phosphate binders are crucial for managing hyperphosphatemia in CKD patients.
- Existing phosphate binders, like lanthanum carbonate, have limitations.
Purpose of the Study:
- To investigate cerium oxide as a potential new phosphate binder.
- To evaluate the efficacy and safety of cerium oxide in vitro and in vivo.
Main Methods:
- Cerium oxide's phosphate adsorption was tested at acidic and neutral pH.
- A 5/6 nephrectomy (5/6Nx) rat model was used for in vivo evaluation.
- Key biochemical markers, food/water intake, and urine/feces volume were analyzed.
Main Results:
- Cerium oxide effectively adsorbed phosphate at pH 2.5 and 7.0.
- In 5/6Nx rats, cerium oxide reduced serum phosphate without inducing hepatotoxicity (elevated ALT).
- Serum creatinine and BUN levels were maintained in cerium oxide-treated rats.
Conclusions:
- Cerium oxide demonstrates potential as an effective phosphate binder.
- Observed changes in body weight and fluid intake in rats were attributed to nephrectomy, not cerium oxide.
- Further research is required to assess long-term safety and cerium accumulation.
