Related Experiment Video
Updated: Sep 2, 2025

Lineage Tracing and Clonal Analysis in Developing Cerebral Cortex Using Mosaic Analysis with Double Markers MADM
Published on: May 8, 2020
Joint inference of ancestry and genotypes of parents from children
1Department of Computer Science and Engineering, University of Connecticut, 371 Fairfield Way, Unit 4155, Storrs, CT 06269-4155, USA.
Abstract:
In this paper, we address a problem: can we perform ancestry inference for parents from one or more children's DNA samples? That is, suppose the parents' genomes consist of segments of different ancestry, and our goal is inferring parental ancestry and at the same time, calling parental genotypes from given children's genetic data. Such ancestry inference may provide insights into recent ancestors from children's genomes, and potentially has applications in understanding genetic traits. At present, there exists no method for this inference problem. We present parMix, a method based on hidden Markov model (HMM) that can jointly infer parental ancestry and call parental genotypes from data of a small number of children. Simulation results show that parMix performs well in practice. It can provide reasonably accurate parental inference given data from a small number (say three) of children. parMix becomes more accurate when data from more children are used.
More Related Videos
Related Concept Videos
Behavioral Genetics and Its Designs
The primary methodologies used in behavior genetics include family studies, twin studies, and adoption studies, each providing unique...
Pedigree Analysis
Inheritance
Each gene exists in pairs, and the combination of these genes from both parents forms an individual's genotype. This genotype is a blueprint of potential traits. Examples of genotype...
Heritability
Genome-wide Association Studies-GWAS
GWAS does not require the identification of the target gene involved in...
Evolutionary Relationships through Genome Comparisons

