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Abrupt decrease in synaptic inhibition in the postnatal rat olfactory bulb.

D A Wilson, M Leon

    Brain Research
    |May 1, 1987
    PubMed
    Summary
    This summary is machine-generated.

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    Synaptic mechanisms in the rat olfactory bulb develop early. Inhibition decreases sharply around postnatal day 19-20, while facilitation is present by day 10.

    Area of Science:

    • Neuroscience
    • Developmental Neuroscience
    • Olfactory System Research

    Background:

    • The olfactory bulb is crucial for processing scent information.
    • Understanding the developmental trajectory of synaptic function is key to olfactory system maturation.

    Purpose of the Study:

    • To investigate the developmental timeline of synaptic inhibition and facilitation in the rat olfactory bulb.
    • To characterize changes in olfactory bulb circuitry during early postnatal development.

    Main Methods:

    • Paired-pulse stimulation of the lateral olfactory tract in urethane-anesthetized rats.
    • Electrophysiological recording of olfactory bulb responses across different postnatal ages (5 days to adult).

    Main Results:

    Related Experiment Videos

  • Brief inter-pulse intervals caused response depression at all ages, decreasing significantly between postnatal days 19-20.
  • Longer inter-pulse intervals revealed response facilitation in adults, evident by postnatal day 10.
  • Presumed granule cell-mediated inhibition was high in the developing bulb, declining sharply around days 19-20.

    • Conclusions:

    • Both inhibitory and facilitatory synaptic mechanisms are present early in rat olfactory bulb development.
    • A significant developmental shift in inhibitory synaptic function occurs around postnatal days 19-20.
    • Olfactory bulb synaptic plasticity mechanisms mature progressively during the early postnatal period.