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Updated: Sep 2, 2025

Characterizing Cell Migration Within Three-dimensional In Vitro Wound Environments
Published on: August 16, 2017
The force of cell-cell adhesion in determining the outcome in a nonlocal advection diffusion model of wound healing
1Mathematics Department, Vanderbilt University, Nashville, TN, USA.
Abstract:
A model of wound healing is presented to investigate the connection of the force of cell-cell adhesion to the sensing radius of cells in their spatial environment. The model consists of a partial differential equation with nonlocal advection and diffusion terms, describing the movement of cells in a spatial environment. The model is applied to biological wound healing experiments to understand incomplete wound closure. The analysis demonstrates that for each value of the force of adhesion parameter, there is a critical value of the sensing radius above which complete wound healing does not occur.
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