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Arterial stiffness and atrial fibrillation: shared mechanisms, clinical implications and therapeutic options

Riccardo Vio1, Andrea S Giordani2, Maria Stefil3

  • 1Department of Cardiothoracic, Vascular Medicine & Intensive Care, Unit of Cardiology, Dell'Angelo Hospital, Mestre-Venice.

Journal of Hypertension
|August 9, 2022
PubMed

Insights

Arterial stiffness (AS) increases the risk of developing atrial fibrillation (AF). Managing AS may improve AF symptoms and treatment effectiveness, offering a new therapeutic target.

Area of Science:

  • Cardiology
  • Vascular Biology
  • Electrophysiology

Background:

  • Arterial stiffness (AS) and atrial fibrillation (AF) share common pathophysiological pathways.
  • AS is a risk factor for AF development.
  • AF patients with AS often experience more symptoms and reduced treatment efficacy.

Purpose of the Study:

  • To review the association between AS and AF.
  • To explore shared molecular and pathophysiological mechanisms.
  • To discuss clinical implications and therapeutic strategies.

Main Methods:

  • Literature review of studies investigating the link between AS and AF.
  • Analysis of shared mechanisms.
  • Evaluation of clinical outcomes and treatment options.

Main Results:

  • AS is a significant risk factor for AF.
  • Measurement of AS (e.g., aortic pulse wave velocity) can be challenging in AF due to arrhythmias.
  • Interventions targeting AS may benefit AF management.

Conclusions:

  • There is a strong bidirectional relationship between AS and AF.
  • Targeting AS reduction presents a promising therapeutic avenue for improving AF management.
  • Further research into de-stiffening interventions for AF patients is warranted.

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