Jove
Visualize
Contact Us

Related Concept Videos

Affinity and Avidity01:41

Affinity and Avidity

36.6K
Overview
36.6K
Antibody Actions01:26

Antibody Actions

1.3K
Antibodies, or immunoglobulins, are critical players in the immune system's arsenal against invading pathogens. Produced by B cells and plasma cells, their primary role is to detect and bind to specific antigens, molecules found on the surface of pathogens like bacteria or viruses. Beyond antigen recognition, antibodies perform several vital functions that contribute to immune defense.
Neutralization
Antibodies can bind to pathogens, preventing them from infecting host cells. This process...
1.3K
Conjugated Proteins02:50

Conjugated Proteins

18.5K
Simple proteins and protein complexes contain only amino acids. In contrast, many other proteins, called conjugated proteins, covalently bond with non-protein moieties.
Nucleoproteins are protein complexes that contain nucleic acids, categorized as deoxyribonucleoproteins (DNPs) or ribonucleoproteins (RNPs) respectively. The nucleosome is a typical example of a DNP where nuclear DNA is associated with histone proteins. The major antigen for the Covid-19 virus SARS-CoV is an RNP that is critical...
18.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Whole genome re-sequencing to identify suppressor mutations of mutant and foreign Escherichia coli FtsZ.

PloS one·2017
Same journal

Bilirubin Reductase from <i>Mediterraneibacter gnavus</i>: Positional Reduction Preferences and Transient-State Analysis.

Biochemistry·2026
Same journal

Aromatic Cage-Directed Azide-Methyllysine Photochemistry for Profiling Nonhistone Interacting Partners of the MeCP2 Methyl-CpG-Binding Domain.

Biochemistry·2026
Same journal

Differential Hydroxypyruvate Processing by <i>E. coli</i> and <i>P. aeruginosa</i> DXP Synthases Reveals Preferential Xylulose 5-Phosphate Formation by the <i>P. aeruginosa</i> Enzyme.

Biochemistry·2026
Same journal

Structural and Functional Characterization of Heterologous Nitrogenase Complexes.

Biochemistry·2026
Same journal

Discovery of Bacterial Unspecific Peroxygenases.

Biochemistry·2026
Same journal

Lactate Biology: Subcellular Routing and Chemical Form Define Function.

Biochemistry·2026
See all related articles
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Sep 2, 2025

Engineering Antiviral Agents via Surface Plasmon Resonance
13:00

Engineering Antiviral Agents via Surface Plasmon Resonance

Published on: June 14, 2022

2.4K

Recently Designed Multivalent Spike Binders Cannot Bind Multivalently─How Do They Achieve Enhanced Avidity to

Harold P Erickson, Lauren Corbin Goodman

    Biochemistry
    |August 9, 2022
    PubMed
    Summary
    This summary is machine-generated.

    Antibody mimics targeting the SARS-CoV-2 spike protein show enhanced binding avidity. This enhanced avidity may be due to rebinding, not simultaneous multivalent binding to a single spike trimer.

    More Related Videos

    Author Spotlight: Advancing Antiviral Strategies Through Novel Immunocapture and Mass Spectrometry Techniques
    08:07

    Author Spotlight: Advancing Antiviral Strategies Through Novel Immunocapture and Mass Spectrometry Techniques

    Published on: January 12, 2024

    826
    A "Plug-And-Display" Nanoparticle Vaccine Platform Based on Outer Membrane Vesicles Displaying SARS-CoV-2 Receptor-Binding Domain
    08:07

    A "Plug-And-Display" Nanoparticle Vaccine Platform Based on Outer Membrane Vesicles Displaying SARS-CoV-2 Receptor-Binding Domain

    Published on: July 25, 2022

    2.7K

    Related Experiment Videos

    Last Updated: Sep 2, 2025

    Engineering Antiviral Agents via Surface Plasmon Resonance
    13:00

    Engineering Antiviral Agents via Surface Plasmon Resonance

    Published on: June 14, 2022

    2.4K
    Author Spotlight: Advancing Antiviral Strategies Through Novel Immunocapture and Mass Spectrometry Techniques
    08:07

    Author Spotlight: Advancing Antiviral Strategies Through Novel Immunocapture and Mass Spectrometry Techniques

    Published on: January 12, 2024

    826
    A "Plug-And-Display" Nanoparticle Vaccine Platform Based on Outer Membrane Vesicles Displaying SARS-CoV-2 Receptor-Binding Domain
    08:07

    A "Plug-And-Display" Nanoparticle Vaccine Platform Based on Outer Membrane Vesicles Displaying SARS-CoV-2 Receptor-Binding Domain

    Published on: July 25, 2022

    2.7K

    Area of Science:

    • Virology
    • Immunology
    • Biochemistry

    Background:

    • The SARS-CoV-2 trimeric spike protein is a key target for antibody mimics designed to neutralize the virus.
    • Previous studies suggested enhanced binding avidity of multivalent constructs due to simultaneous binding to multiple sites on a single spike trimer.

    Purpose of the Study:

    • To investigate the mechanism behind the enhanced binding avidity observed in multivalent antibody mimics targeting the SARS-CoV-2 spike protein.
    • To challenge the prevailing hypothesis of simultaneous multivalent binding within a single spike trimer.

    Main Methods:

    • Analysis of peptide linker lengths (15-20 amino acids) in multivalent constructs using a worm-like-chain model.
    • Theoretical evaluation of the spatial constraints for simultaneous binding to a single spike trimer.

    Main Results:

    • The short peptide linkers (15-20 amino acids) are likely too short to span the binding sites within a single SARS-CoV-2 spike trimer.
    • The observed enhanced avidity is more plausibly explained by a rebinding mechanism.

    Conclusions:

    • The enhanced binding avidity of multivalent antibody mimics against SARS-CoV-2 spike protein is unlikely to result from simultaneous binding to a single spike trimer.
    • A rebinding mechanism offers a more viable explanation for the increased avidity of these constructs.