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Updated: Sep 2, 2025

Spot Variation Fluorescence Correlation Spectroscopy for Analysis of Molecular Diffusion at the Plasma Membrane of Living Cells
Published on: November 12, 2020
Blocker Effect on Diffusion Resistance of a Membrane Channel: Dependence on the Blocker Geometry
Leonardo Dagdug1,2, Alexei T Skvortsov3, Alexander M Berezhkovskii2
1Departamento de Fisica, Universidad Autonoma Metropolitana-Iztapalapa, 09340 Mexico City, Mexico.
None:
Being motivated by recent progress in nanopore sensing, we develop a theory of the effect of large analytes, or blockers, trapped within the nanopore confines, on diffusion flow of small solutes. The focus is on the nanopore diffusion resistance which is the ratio of the solute concentration difference in the reservoirs connected by the nanopore to the solute flux driven by this difference. Analytical expressions for the diffusion resistance are derived for a cylindrically symmetric blocker whose axis coincides with the axis of a cylindrical nanopore in two limiting cases where the blocker radius changes either smoothly or abruptly. Comparison of our theoretical predictions with the results obtained from Brownian dynamics simulations shows good agreement between the two.
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