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Oscillatory Mechanics Response to Inhaled Bronchodilators in Very Preterm Infants: A Retrospective Study

Camilla Rigotti1, Emanuela Zannin1, Chiara Veneroni2

  • 1Neonatal Intensive Care Unit, Fondazione Monza e Brianza per il Bambino e la sua Mamma (MBBM), Monza, Italy.

The Journal of Pediatrics
|August 9, 2022
PubMed

Insights

Forced oscillation technique (FOT) shows reliable lung function measurements in preterm infants. Some infants respond to bronchodilators (BDs), indicating FOT can personalize BD treatment.

Area of Science:

  • Pediatric Pulmonology
  • Respiratory Physiology
  • Neonatal Medicine

Background:

  • Preterm infants often experience respiratory complications requiring lung function assessment.
  • The forced oscillation technique (FOT) offers a non-invasive method for evaluating lung function.
  • Assessing response to bronchodilators (BDs) is crucial for managing respiratory conditions in this population.

Purpose of the Study:

  • To determine the short-term repeatability of lung function measurements using FOT.
  • To evaluate the response of lung function to BDs in preterm infants via FOT.
  • To establish if FOT can identify preterm infants who benefit from BDs.

Main Methods:

  • Retrospective analysis of respiratory system resistance and reactance measured by FOT.
  • Calculation of the coefficient of repeatability for FOT measurements.
  • Assessment of BD responsiveness by comparing pre- and post-salbutamol FOT measurements.

Main Results:

  • The coefficient of repeatability was 7.5 cmH2O*s/L for resistance and 6.3 cmH2O*s/L for reactance.
  • Respiratory system reactance significantly increased post-BD administration (P < .001).
  • BD responsiveness, exceeding the repeatability threshold, was observed in 34% of occasions.

Conclusions:

  • A threshold for assessing BD responsiveness using FOT in preterm infants was identified.
  • FOT shows potential for assessing and personalizing BD treatment in preterm infants.
Abstract

Keywords:
bronchodilator agentsbronchopulmonary dysplasiainfantlung mechanicsoscillometrypremature

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