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Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
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Urinary incontinence in systemic sclerosis: a prospective multicentre cohort study.
Gregor John1,2, Elisabetta Zanatta3, Pamela Polito3
1Department of Internal Medicine, Neuchâtel Hospital Network, Rue de la Maladière 45, CH-2000, Neuchâtel, Switzerland. gregor.john@rhne.ch.
Rheumatology International
|August 9, 2022
Summary
Urinary incontinence in systemic sclerosis is dynamic, frequently changing subtypes and severity over time. However, it did not significantly impact hospital admissions, mortality, or quality of life in this study.
Area of Science:
- Rheumatology
- Urology
- Clinical Epidemiology
Background:
- Systemic sclerosis (SSc) is a chronic autoimmune disease with diverse manifestations.
- Urinary incontinence (UI) is a common but understudied complication in SSc patients.
- Understanding the natural history and impact of UI in SSc is crucial for patient management.
Purpose of the Study:
- To investigate the longitudinal course of urinary incontinence in patients with systemic sclerosis.
- To identify factors associated with the development and progression of UI in SSc.
- To assess the impact of UI on quality of life, hospital admissions, and mortality in SSc.
Main Methods:
- A 5-year international observational study of 189 SSc patients.
- Serial self-administered questionnaires assessed UI presence, subtype, severity, and quality of life.
- National death registries provided mortality data; multilevel mixed-effect logistic and Cox regression models were used for analysis.
Main Results:
- Annual incidence of new-onset UI was 16.3% and remission was 20.8%.
- Over 57% of UI patients experienced subtype changes; 35% reported milder or resolved UI.
- UI at baseline did not significantly correlate with hospital admission, mortality, or changes in quality of life.
Conclusions:
- Urinary incontinence in SSc is a highly dynamic condition, characterized by fluctuations in severity and frequent subtype changes.
- Factors such as anti-centromere antibodies, digestive symptoms, and comorbidities influence UI development.
- Despite its dynamic nature, UI in SSc did not demonstrate a significant association with adverse clinical outcomes like hospitalization or mortality in this cohort.
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